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Flashcards in Board Review Course Deck (15):
1

What are the 5 broad families of pattern recognition receptors?

leucine rich repeat (TLRs & NLRs), RNA sensing RIG-I receptors (RLRs), DEeD/Hbox Helicase (DDX), PYHIN, C type lectin receptors (CLRs)

2

What PRRs are on the cell surface?

TLRs, CLRs

3

What PRRs are on endosomal surface?

TLRs

4

What PRRs are cytoplasmic?

RLRs, NLRs

5

What are the CD markers for flow for TRECs?

CD4+, CD45RA, CD31+

6

What is the cut off that is considered absolute lymphopenia in infants? T cell lymphopenia cut off?

<3000 cells/mm3; <2000 cells/mm3, respectively

7

What is sensitivity?

% of positive tests that indicate actual presence of disease; TP/TP+FN x 100

8

What is specificity?

% of negative tests that correspond with absence of disease; TN/TN + FP x 100

9

What is positive predictive value?

the frequency of disease in all patients with a positive test; TP/TP+FP x 100

10

What is negative predictive value?

frequency of patients without disease in all patients with a negative test; TN/TN+FN x 100

11

What is the mutation in TRAPs?

TNFRSF1A (encodes p55 receptor); dominant mutation; weeks of fever, serositis, arthritis, migratory rash and periodontal edema

12

hyper IgD

mutation in MVK; early life fevers, diarrhea, cervical adenopathy and apthuous ulcers; triggered by stress, imms, etc. Dutch and Northern Europeans

13

what is the difference between tuberculoid leprosy and lepromatous leprosy?

these two forms (caused by the same mycobacteria) are on polarized ends of the spectrum depending on their initial immune response. Tuberculoid leprosy is Th1 response with granulomas that can cause nerve damage, but otherwise well-contained and low infectivity. Lepromatous leprosy has a Th2 response that leads to poor control of the infection and widespread tissue destruction and macrophages do not get activated to kill the pathogen. Hypergamm and often anergy to M. leprae and other pathogens

14

what viral protein is expressed by EBV virus that acts as a defense mechanism and can produce anergy in the host?

vIL-10, homologous to IL-10 which can inhibit a Th1 type response

15

how does the measles virus induce anergy as a defensive mechanism?

binds to CD46 on monocytes and inhibits their production of IL12