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Pathology > Ch 10 > Flashcards

Ch 10 Flashcards

(68 cards)

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1
Q

What HPV causes Verruca Vulgaris

A

2
4
6
40

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2
Q

What is the most common color of V V oral lesions

A

White

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3
Q

What is the differential for Squamous papilloma

A

Verruca Vulgaris
Condyloma Acuminatum
Verruciform Xanthoma

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4
Q

What HPV is squamous papilloma caused by

A

6

11

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5
Q

What is the most common site for V V

A

hands

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6
Q

What is another name for condyloma cuminatum

A

venereal wart (STD)

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7
Q

What HPV cause Condyloma cuminatum

A

2
6 and 11 most common

16, 18, 31 high risk
53
54

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8
Q

What is the average size of condyloma acuminatum

A

1-1.5cm twice as large as the others

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9
Q

What two HPV represent increased risk for squamous cell carcinoma in anogenital area

A

16

18

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10
Q

what is another name for multifocal epithelial hyperplasia

A

Heck’s disease

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11
Q

What HPV cause multifocal epithelial hyperplasia

A

13

32

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12
Q

What is the Tx for multifocal epithelial hyperplasia

A

Nothing, they spontaneously regress.

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13
Q

What virus type is molluscum contagiousum caused by

A

DNA poxvirus

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14
Q

What is a histopathology sign of molluscum contagiousum

A

molluscum bodies/ Henderson-Paterson bodies

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15
Q

What are xanthoma cells

A

lipid-laden histiocytes

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16
Q

What for of seborrheic keratosis occurs in aa

A

Papulosa nigra

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17
Q

What is the sudden appearance of numerous seborrheic keratoses called

A

Leser-Trelat sign

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18
Q

Actinic Keratosis is caused by

A

Cumulative UV radiation

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19
Q

Metastatic spread is largely via

A

Lymphatics

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20
Q

What is TNM

A

o T = size of primary local tumor in centimeters
o N = Involvement of local lymph nodes
o M = Distant metastasis

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21
Q

What is field cancerization

A

tendency towards development of multiple mucosal cancers

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22
Q

What is the lip version of actinic keratosis called

A

Actinic cheilosis

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23
Q

When should actinic cheilosis should be biopsied

A

Induration
thickening
Ulceration

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24
Q

What syndrome pts have an increased risk for SCCA

A

Plummer-Vinson

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25
What are the most common intraoral SCCA sites in order
1) Tongue: posterior lateral and ventral 2) FOM 3) Soft palate 4) Gingiva
26
Lymphatic nodes that have been infected by SCCA present as
Firm to stony hare Painless Enlarged Fixed
27
What are the most common sites for verrucous carcinoma
Mandibular vestibule | Gingiva
28
Nashopharyngeal carcinoma is associated with what virus
EBV
29
Consumption of what might lead to nasopharyngeal carcinoma
salt fish with N-nitrosamines
30
What cancer is the most common
Basal cell carcinoma
31
What is the most common form of basal cell carcinoma
nodular; noduloulcerative
32
What does basal cell carcinoma look like
papule with telangiectatic blood vessels, umbilicated with rolled borders.
33
What is the ABCDE of melanona
``` Asymmetry; one half is different from the other Border; Irregular, notched or blurry Color; more than one Diameter; larger than 6mm Evolving lesions ```
34
What skin cancer accounts for the most deaths
Melanoma; third most common skin cancer but accounts for the most deaths.
35
What two directional patterns does melanoma present
Radial; horizontal spread through basal layer--> flat lesion followed by Vertical; invasion of underlying connective tissue--> Tumor
36
How big of a surgical excision margin is used for melanoma
3-5 cm
37
What is the BANS of melanoma
Back; Interscapular area Arm; posterior upper Neck; Posterior and lateral Scalp
38
What is the prognosis for oral melanoma
extremely poor
39
What are the most common sites for squamous papilloma
Tongue lips soft palate
40
How does squamous papilloma present clinically
Painless usually pedunculated Exophytic white, red or mucosal color
41
Where is the most common site for verruciform xanthoma
gingiva
42
The blue color of a blue nevus is due to
Tyndall effect
43
What is the definition of leukoplakia
an intraoral white plaque that does not rub off and cannot be identified as any other well known entity.
44
What are some white lesions that can be scraped off
``` Materia alba white coated tongue burn Pseudomembranous candidiasis sloughing from toothpaste ```
45
What is the etiology of leukoplakia
``` tobacco alcohol sanguinaria UV rad microorganisms trauma ```
46
Where are 70% of leukoplakia lesions found
lip vermilion buccal mucosa gingiva
47
Leukoplakia with 90% dysplasia or carcinoma is found in
Lip vermillion lateral/ventral tongue FOM
48
lesions that demonstrate scattered red patches are termed
erythroplakia
49
Red and white intermixed lesions are termed
erythroleukoplakia
50
What does PVL stand for
Proliferative verrucous leukoplakia
51
Does PVL have an association with tobacco use
No
52
What % of leukoplakias become SCCA and within what time frame
5% within 2-4 yrs
53
What factors increase the risk for cancer in leukoplakia
persistent over several years female ptn Non-smoker FOM or ventral tongue lesions
54
Smokeless tobacco keratosis presents with NO
Induration ulceration Pain
55
What disease is linked to chronic placement of betel quid or paan
Oral submucous fibrosis
56
What is quid
``` Areca nut slaked lime betel leaf tobacco sweteners ```
57
What is the CC of oral sub mucous fibrosis
trismus | mucosal pain from eating spicy foods
58
What are 12 possible contributors to SCCA
``` o Tobacco o Betel Quid o Alcohol o Phenolic agents o Radiation o Iron deficiency o Vitamin-A deficiency o Syphilis o Oncogenic viruses o Immunosuppression o Oncogenes o Tumor suppressor genes ```
59
What is the relative risk fro oral SCCA for a smoker
``` 2ppd= 5 4ppd= 17 ```
60
Wood industry workers are exposed to ---- leading to SCCA
phenoxyacetic acids
61
Vitamin A deficiency leads to excessive prod of
keratinization
62
What HPV viruses are considered oncogenic
16 18 31 33
63
Distant metastasis is most commonly found in
Lungs Liver Bones
64
Meaning of X following TNM
No available information
65
Meaning of O following TNM
No evidence of distant metastasis
66
What carcinoma has a "deceptively benign" microscopic appearance
Verrucous carcinoma
67
Melanoma invasions > ___ mm in oral mucosa has poor diagnosis
0.5 mm
68
What are the histologic categories for leukoplakia
Mild 1/2 | Carcinoma in situ

Pathology (17 decks)

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