Ch 13 - Psychopharmocology

Question 0

drugs produced from outside the body

Answer 0

exogenous

Question 1

drugs produce from within

Answer 1

endogenous

Question 2

how a drug works

Answer 2

effects

Question 3

where a drug works

Answer 3

site of action

Question 4

how a drug gets used

Answer 4

pharmacokinetics

Question 5

to affect you, a drug must blank

Answer 5

bind to a receptor

Question 6

faster a drug gets to site of action, the more blank

Answer 6

addictive

Question 7

after a certain dose of drug, increasing doses blank

Answer 7

does not produce stronger effect

Question 8

difference between desired effect and undesired effect like mortality

Answer 8

margin of safety

Question 9

takes a higher dose to get the same effect

Answer 9

tolerance

Question 10

dose of a drug creates augmented effect… and locomotor activity increases as well as WANT for the drug

Answer 10

sensitization

Question 11

a substance from which another substance is formed

Answer 11

precursor

Question 12

drugs that facilitate postsynaptic effects

Answer 12

agonist

Question 13

drugs that block postsynaptic effects

Answer 13

antagonist

Question 14

competitive binding of agonists and antagonists

Answer 14

direct

Question 15

noncompetitive binding of agonists and antagonists

Answer 15

indirect

Question 16

neurotransmitters must be:

Answer 16

1. in synaptic terminal
2. calcium dependent release
3. subject to inactivation
4. receptors exist

Question 17

3 nt families

Answer 17

amino acids, monoamines, neuropeptides

Question 18

glutamate, aspartate, glycine, gaba are blank NTs

Answer 18

amino acids

Question 19

catecholamines, indoleamines, histamine, acetlycholine are blank NTs

Answer 19

monoamines

Question 20

substance P, endorphins, enkephalins are blank NTs

Answer 20

neuropeptides

Question 21

90% of CNS involve the 4 blank neurotransmitters

Answer 21

amino acid

Question 22

glutamate and aspartate are blank NTs

Answer 22

excitatory

Question 23

gaba and glycine are blank NTs

Answer 23

inhibitory

Question 24

major inhibitory CNS neurotransmitter

Answer 24

gaba

Question 25

gaba is made from blank and blank

Answer 25

glutamade, gad

Question 26

glutamate and gad makes these two things

Answer 26

gaba, co2

Question 27

chloride concentration is blank inside than outside

Answer 27

less

Question 28

two gaba indirect agonists

Answer 28

valium, phenobarbital

Question 29

gaba a receptors allow blank ions in

Answer 29

chloride

Question 30

gaba b receptors are connected to blank channels

Answer 30

potassium

Question 31

precursor of dopamine, norepinephrine, epinephrine

Answer 31

tyrosine

Question 32

precursor of serotonin

Answer 32

tryptophan

Question 33

first man to isolate neurotransmitter

Answer 33

otto loewi

Question 34

two ach receptor subtypes

Answer 34

muscarinic, nicotinic

Question 35

sympathetic has blank synapses, releases blank at first and blank at second

Answer 35

2, ach, norepinephrine

Question 36

parasympathetic has blank synapses, releases blank at first and blank at second

Answer 36

2, ach, ach

Question 37

somatic has blank synapses and releases blank

Answer 37

1, ach

Question 38

dopamine, norepiniphrine, epinephrine are all this type of monoamine

Answer 38

catecholamine

Question 39

serotonin is this type of monoamine

Answer 39

indoleamine

Question 40

tyrosine through tyrosine hydroxylase is converted to blank and is the rate limiting step

Answer 40

dopa

Question 41

dopa becomes blank through aromatic amino acid decarboxylase

Answer 41

dopamine

Question 42

dopamine is converted to blank via dopamine beta hydroxylase

Answer 42

norepinephrine

Question 43

norepinephrine is converted to blank via pnmt

Answer 43

epinephrine

Question 44

only two places that make dopamine

Answer 44

substantia nigra, ventral tegmental area

Question 45

vta, substantia nigra are in the blank

Answer 45

midbrain/mesencephalon

Question 46

pathway of dopamine that is reinforcement, drug addictino, schizo

Answer 46

mesolimbic

Question 47

mesolimbic has dopamine coming from this part of vta

Answer 47

nucleus accumbens, amygdala

Question 48

dopamine for STM, and planning

Answer 48

mesocortical

Question 49

mesocortical has dopamine coming from this part of vta

Answer 49

prefrontal cortex

Question 50

pathway of dopamine for movement and comes from substantia nigra

Answer 50

nigrostriatal

Question 51

norepinephrine uses axonal blank

Answer 51

varicosities

Question 52

cocaine causes blank effect of dopamine

Answer 52

prolonged

Question 53

tryptophan is converted to blank via tryptophan 5-hydroxylase and is the blank

Answer 53

5 htp, rate limiting step

Question 54

5 htp is converted to blank via aromatic amino acid decarboxylase

Answer 54

5 ht (serotonin)

Question 55

serotonin is released blank the brain rather than specific blank

Answer 55

throughout, pathways

Question 56

serotonin is made in blank

Answer 56

raphe nuclei

Question 57

mao inhibitor mess with blank and are for blank

Answer 57

monoamine oxidase, depression

Question 58

ssri blocks the blank of serotonin and are for blank

Answer 58

reuptake, depression

Question 59

peptide transmitters have recently been found to act as transmitters in the blank

Answer 59

cns

Question 60

peptides may blank other neurotransmitters

Answer 60

modulate

Question 61

there is blank of peptides with classical neurotransmitters

Answer 61

colocalization

Question 62

the study of the effects of exogenous drugs on the nervous system and behavior

Answer 62

psychopharmacology

Question 63

drugs can modulate blank in many different ways

Answer 63

neurotransmitters

Question 64

first natural ligand for thc discovered

Answer 64

anandamide

Question 65

thc stimulates blank receptors in cerebellum, globus pallidus, hippocampus, and substantia nigra

Answer 65

cannabioid

Question 66

there are blank receptors for marijuana in blank

Answer 66

few, brainstem

Question 67

thc has a low blank

Answer 67

toxicity

Question 68

drug that distorts visual perception / serotonin

Answer 68

lsd

Question 69

drug that is a noradrenergic/serotonergic agonist, excitatory and hallucinogenic effects; short term feeling of euphoria and well being

Answer 69

mdma (ecstasy)