ch 15: introduction to the immune response Flashcards
known as immunoglobulin, produced in b plasma cells in response to a specific protein ; react with that protein to cause its destruction directly or through activation of the inflammatory response
antibodies
foreign protein
antigen
released in the injured cells to stimulate inflammatory response through an activation of various substances
arachidonic acid
a disorder that occurs when the body repsonse to specific self antigen to produce antibodies againsts its own cells
autoimmune disease
these are lymphocytes programmed to recognize specific proteins; when activated, these cells cause the production of antibodies to react with that protein
b cells
heat, one if the caridnal signs of inflamamtion
calor
five cardinal signs, namely
redness (rubor), swelling (tumour), heat (calor; only applicable to the body’ extremities), pain (dolor) and loss of function (functio laesa)
chemotaxis
property of drawing neutrophils to an infected area
series of cascading proteins that react with the antigen-antibody complex to destroy the protein or stimulate an imflammatory response dolor (one of the cardinal signs of inflammation)
complement proteins
first factor activated when a blood vessle or cell is injured; starts the cascading reaction of the clotting factor, activates the conversion of plasminogen to plasmin to dissolve clots, and activates kinin system responsible for activation of the inflammatory response
hageman factor
are proteins that protect the body against viral infection
interferon
why interferon called “save yourself”
interferon binds to the surface of the neighboring cells where theystimulate antiviral proteins, , which dont protect the cell that produces them
tissue hormone that is released in reponse to viral invasion; block viral replication
interferon
chemicals released by whote blood cells to communicate with other WBCs and to support the inflammatory and immune reactions
interleukins
activated by hageman factor as part of the inflammatory response, includes bradykinin
kinin system
is a potent endothelium-dependent vasodilator and mild diuretic, which may cause a lowering of the blood pressure. It also causes contraction of non-vascular smooth muscle in the bronchus and gut, increases vascular permeability and is also involved in the mechanism of pain.
Bradykinin
is a poorly understood hormonal system with limited available research. It consists of blood proteins that play a role in inflammation, blood pressure control, coagulation and pain.
kinin system
can be whiteblood ells ; canbr nuetrophils, basophils and eosinophils
leukocytes
are motile white blood cells that leave the blood and enter infected tissues
basophils
whiteblood cells that is associated with allergies and asthma
eosinophils
large white blood cells with large nuclei can be t cells or b cells
lymphocytes
genetic identification code carried on a chromosome ; produces several proteins /antigens that allow the body to recognize cells as being self-cells
major histocompatibility complex
mature leukocytes that are capable of phagocytizing an antigen; also called monocytes or mononuclear phagocytes
macrophage
fixed basophils found in the repiratory , GI tract, skin which relases chemical mediators of the inflammatory and immune responses when they are stimulated by local irritation
mast cells