Ch. 18 Neurobiology of Schizophrenia, Mood Disorders, and Anxiety Disorders

Question 1

Which of the following BEST describes schizophrenia?
  Positive personality
  Negative personality
  Disruption of thoughts
  Constant hallucinations

Answer 1

Disruption of thoughts

Question 2

Which of the following is a TRUE statement regarding the epidemiology of schizophrenia?
If a mother has twins, both twins will have schizophrenia 100% of the time.
Ten percent of the general population will have schizophrenia.
It is a simple genetic transmission.
Concordance between siblings is 15%.

Answer 2

Concordance between siblings is 15%

Question 3

A schizophrenic woman becomes pregnant. Which of the following is a TRUE statement regarding her offspring?
Schizophrenia may result from neurodevelopmental defects.
Research does not indicate any environmental involvement in schizophrenia.
An early brain effect manifests immediately.
There are no suspected alterations in brain structure.

Answer 3

Schizophrenia may result from neurodevelopment defects

Question 4

Which of the following abnormalities have been documented in schizophrenic brains?
Increased reelin in prefrontal cortex
Decreased reelin in interneurons containing GABA
Decreased glutamic acid decarboxylase
Increased reelin in hippocampus

Answer 4

Decreased glutamic acid decarboxylase

Question 5

Which of the following drugs may actually cause psychosis at high doses?
  Levodopa 
  Chlorpromazine
  Fluphenazine
  Haloperidol

Answer 5

Levodopa

Question 6

Which of the following is a TRUE statement regarding dopamine in relation to schizophrenia?
Negative symptoms result from increased dopaminergic transmission.
Increased secretion of dopamine may contribute to positive symptoms.
It is involved in learning and memory.
It is found in increased concentrations in CSF.

Answer 6

Increased secretion of dopamine may contribute to positive symptoms

Question 7

Which of the following is NOT one of the three dimensions of schizophrenia?
  Psychotic symptoms
  Negative symptoms
  Disorganized symptoms
  Neutral symptoms

Answer 7

Neutral symptoms

Question 8

A man states he is hearing voices instructing him to steal money from the church. This perception is which of the following?
  Delusion
  Disorganized speech
  Disorganized behavior
  Hallucination

Answer 8

Hallucination

Question 9

An individual suffering from schizophrenia is unable to experience emotions, especially pleasure. Which of the following terms describes this?
  Alogia
  Avolition
  Anhedonia 
  Aphasia

Answer 9

Anhedonia

Question 10

Which of the following is a TRUE statement regarding a mood disorder?
It is a sustained emotional state.
It is a disruption of thought.
Lifetime prevalence rate for depression is 1%.
Two percent of those with major depression develop bipolar disorder.

Answer 10

It is a sustained emotional state

Question 11

Which of the following is TRUE regarding mood disorders?
The hypothalamic-pituitary-adrenal (HPA) system hormones are decreased in a large percentage of individuals with major depression.
Depression occurs with deficits in brain norepinephrine.
Environmental factors have no role in depression.
There is no genetic role in depression.

Answer 11

Depression occurs with deficits in brain norepinephrine