Ch 28 Peptic Ulcer Disease Flashcards Preview

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Flashcards in Ch 28 Peptic Ulcer Disease Deck (18)
0

What groups of medications is used to treat peptic ulcer disease

Antibiotics
Anti secretory agents ( H2 receptor antagonists and PPI)
Mucosal protectants
Antacids

1

What antibiotics are used to treat peptic ulcer disease

Amoxicillin ( Amoxil)
bismuth ( Pepto bismol)
Clarithromycin ( Biaxin)
Metronidazole ( flagyl)
Tetracycline ( achromycin V, Sumycin)

2

What is the pharmalogical action of antibiotics in the treatment of peptic ulcer disease

Eradication of H pylori bacteria
Therapy should include combination of 2-3 antibiotics for 14 days to increase effectiveness and to mimimize the development of drug resistance.

3

What are common adverse effects of antibiotics

Nausea
Diarrhea

4

What are histamine2 receptor antagonists

They suppress the secretion of gastric acid by selectively blocking H2 receptor in parietal cells lining the stomach.
They are used in combinations with antibiotics to treat ulcers caused by H pylori.
Is prescribed for gastric and peptic ulcers, GERD, and hypersecretory conditions such as Zollinger Ellison syndrome.

5

What are adverse effects of H2 receptor antagonists

Cimetidine may block androgen receptors resulting in decreased libido and impotence. It may also cause CNS effects ( lethargy, depression, confusion.)

6

What is the prototype drug of histamine 2 receptor antagonists

Ranitidine Hydrochloride ( Zantac)
Cimetidine ( Tagamet)
Famotidine ( Pepcid)
Nizatidine ( Axid) PO use only!!!

7

What are contraindications and precautions of histamine 2 receptor antagonists

Pregnancy category B
Use in older adults can cause anti adrenergic effects ( impotence) and CNS effects ( confusion)
H2 receptor antagonists decrease gastric acidity, which promotes bacterial colonization of the stomach and secondary of the respiratory tract....uses cautiously in ppl at high risk for pneumonia, such as ppl with COPD.

8

What are medication interactions of h2 antagonizes

Cimetidine can inhibit medication metabolizing enzymes and thus increases the levels of warfarin, phenytoin, theophylline and lidocaine.
Concurrent use of antacids can decrease absorption of histamine2 receptor antagonists

9

What is treatment of peptic ulcer disease

Treatment is usually started as an oral dose twice a day until the ulcer is healed, followed by a maintenance dose which is usually given at bedtime.

10

What is a proton pump inhibitor

They reduce gastric acid secretion by irreversibly inhibiting the enzyme that produces gastric acid
PPIs reduce basal and stimulated acid production

They are prescribed for gastric and duodenal ulcers, erosive esophagitis, GERD, and hypersecretory conditions such as Zollinger Ellison syndrome.

11

Name the prototype proton pump inhibitor and other drugs

Omerprazole ( Prilosec)
Pantoprazole ( protonix)
Lansoprazole ( Prevacid) dexlansoprazolem( Dexilant)
Rabeprazole sodium ( AcipHex)
Esomeprazole ( Nexium)

12

Long term use of proton pump inhibitors increase the risk for what

Osteoporosis

13

What are contraindications and precautions of H2 receptor antagonists and proton pump inhibitor

These meds increase the risks for pneumonia use cautiously in COPD clients

14

When used concurrently with Omerprazole, what drugs serum levels will be increased

Digoxin
Phenytoin
Warfarin

15

The absorption of what drugs is decreased significantly when used with proton pump inhibitors

Ketoconazole
Itraconazole ( sporanox)
Atazanavir ( reyataz)

Concurrent use should be avoided if necessary to administer, separate by 2-12 hr.

16

What time of the day should Omerprazole be administered

Once a day in the morning prior to eating

17

What proton pump inhibitor can be administered orally

Pantoprazole ( protonix)