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Flashcards in ch 5 clinical aspects Deck (10):
1

in chronic exposure to irritants and metaplasia in the upper resp tract:
-___ cells increase, so increased mucus
-___ ___ decrease so congestion increases
-___glands increase in SIZE, so more fluid

goblet
ciliated columnar
seromucus

2

with chronic exposure to irritants, if much coughing then may develop patches of ___ ___ epi instead of respiratory epi (metaplasia)

stratified squamous

3

respiratory distress of the newborn (RDS) AKA

hyaline membrane disease

4

RDS is caused by too few MATURE alveolar __ _ cells

type II

5

two tx for RDS

artificial surfactant & CPAP
glucocorticoids (induce surfactant prod)

6

emphysema occurs w/ a decrease in ____ so decreased alveolar elasticity and a reduced surface for __ __
-irreversible

elastin
gas exchange

7

two common causes of emphysema

inflammation (infection, irritant, smoking)
genetic condition

8

in emphysema, inflammation attracts ___ and ___ which secrete elastase

macrophages
neutrophils

9

protein that protects elastic fibers, is produced by hepatocytes
-is inactivated by free rads from cig smoke

alpha1-antitrypsin

10

___ produce alpha 1-AT but cannot release it therefore levels are too low in the genetically dominant condition that can cause emphysema

hepatocytes