Ch. 50

Question 1

Types of Acid-Controlling Drugs

Answer 1

Antacids
H2 Antagonists
Proton Pump Inhibitors

Question 2

Aluminum carbonate

Answer 2

Aluminum Salt

Question 3

Hydroxide salt

Answer 3

Aluminum Salt

Question 4

Gaviscon

Answer 4

Combination aluminum and magnesium

Question 5

Maalox

Answer 5

Combination aluminum and magnesium

Question 6

Mylanta

Answer 6

Combination aluminum and magnesium

Question 7

Di-Gel

Answer 7

Combination aluminum and magnesium

Question 8

hydroxide salt

Answer 8

Magnesium Salt

Question 9

carbonate salt

Answer 9

Magnesium Salt

Question 10

Tums

Answer 10

calcium salt (Ca Carbonate)

Question 11

Highly soluble. Buffers the acidic properties of HCL. Quick onset, but short duration. May cause metabolic alkalosis. Sodium content may cause problems in patients with
HF, hypertension, or renal insufficiency

Answer 11

Sodium Bicarbonate

Question 12

activated charcoal

Answer 12

Antiflatulant

Question 13

simethicone

Answer 13

Anitflatulant

Question 14

Alters elasticity of mucus-coated bubbles, causing

them to break

Answer 14

simethicone

Question 15

Adverse effect of aluminum and calcium

Answer 15

constipation

Question 16

Adverse effect of magnesium

Answer 16

diarrhea

Question 17

Adverse effects produces gas and belching; often combined with
simethicone

Answer 17

calcium carbonate

Question 18

Chemical binding, or inactivation, of another drug. Produces insoluble complexes. Result: reduced drug absorption

Answer 18

Chelation

Question 19

Drug Interations of Antacids include: Increased absorption of basic drugs. Decreased absorption of acidic drugs as a result of:

Answer 19

Increased stomach pH

Question 20

Interations of Antacids include: Increased excretion of acidic drugs
and decreased excretion of basic drugs as a result of:

Answer 20

Increased urinary pH

Question 21

cimetidine

Answer 21

H2 Anatagonist

Question 22

nizatidine

Answer 22

H2 Anatagonist

Question 23

famotidine

Answer 23

H2 Anatagonist

Question 24

ranitidine

Answer 24

H2 Anatagonist

Question 25

MOA: block receptors of acid-producing parietal cells, therefore production of hydrogen ions is reduced, resulting in decreased production of HCl

Answer 25

H2 Antagonists

Question 26

Indications: GERD, PUD, erosive esophagitis, adjunct therapy in control of upper GI bleeding, pathologic gastric hypersecretory conditions

Answer 26

H2 Antagonists

Question 27

May induce impotence and | gynecomastia

Answer 27

cimetidine

Question 28

MOA: Irreversibly bind to H + /K + ATPase enzyme, this bond prevents the movement of hydrogen ions from the parietal cell into the stomach. Result: gastric acid secretion is temporarily blocked

Answer 28

Proton Pump Inhibitors

Question 29

lansoprazole

Answer 29

Proton Pump Inhibitor

Question 30

omeprazole

Answer 30

Proton Pump Inhibitor

Question 31

rabeprazole

Answer 31

Proton Pump Inhibitor

Question 32

pantoprazole

Answer 32

Proton Pump Inhibitor

Question 33

esomeprazole

Answer 33

Proton Pump Inhibitor

Question 34

Indications: GERD maintenance therapy, erosive esophagitis, short-term treatment of active duodenal and benign gastric ulcers, Zollinger-Ellison syndrome, treatment of H. pylori –induced ulcers (administered with an antibiotic)

Answer 34

Proton Pump Inhibitors

Question 35

Cytoprotective drug. Used for stress ulcers, PUD. Attracted to and binds to the base of ulcers and erosions, forming a protective barrier over these areas. Protects these areas from pepsin, which normally breaks down proteins (making ulcers worse

Answer 35

sucralfate

Question 36

A synthetic prostaglandin analog. Protects gastric mucosa from injury by enhancing local production of mucus or bicarbonate. Promote local cell regeneration. Help to maintain mucosal blood flow

Answer 36

misoprostol

Question 37

Used for prevention of NSAID-induced gastric | ulcers

Answer 37

misoprostol

Question 38

Antiflatulent drug. Used to reduce the discomforts of gastric or intestinal gas (flatulence). Alters elasticity of mucus-coated gas bubbles, breaking them into smaller ones  Decreases gas pain and increases expulsion via mouth or rectum

Answer 38

simethicone