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ns and behavior > Ch 6 > Flashcards

Ch 6 Flashcards

(52 cards)

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1
Q

What are the components of a synapse?

A

Presynaptic terminal
Postsynaptic terminal
Synaptic cleft

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2
Q

What are the steps of synaptic communication?

A
  1. action potential at presyn terminal
  2. membrane depolariz (Ca channel open)
  3. Ca -> synaptic vesicles go to release site
  4. synaptic vesicles release NT
  5. NT diffuses across synaptic cleft
  6. Nt -> receptor
  7. receptor changes shape (open channel assoc w/ receptor or activate intracellular messenger associated w/ receptor)
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3
Q

EPSP

A

Excitatory postsynaptic potential

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4
Q

T/F: EPSP causes hyperpolariz

A

F: ESPS causes depolarization (ion channel open -> less negative)

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5
Q

EPSP involves flow of Na+ and Ca2+ ___ neuron

A

Into

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6
Q

Every action potential in a ___ neuron elicits an EPSP

A

Motor

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7
Q

IPSP causes ___

A

Hyperpolariz

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8
Q

T/F: IPSP involve flow of Cl- into cell and K+ out of cell

A

T

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9
Q

T/F: EPSP = depolarization (less negative -> action potential), and IPSP = hyperpolarization (more negative)

A

T

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10
Q

Presynaptic facilitation = ___ NT released, presyn inhibition =___ NT released

A

More
Less

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11
Q

FM IL

A

presynaptic Facilitation -> More
presynaptic Inhibition -> Less

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12
Q

T/F: presyn facilitation = hyperpolarization

A

F: depolarization

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13
Q

Define neuromessenger agonist

A

When drug binds- receptor and mimics effect of naturally occurring messengers

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14
Q

Define neuromessenger antagonist

A

When drug prevents release of neuromessengers or binds to receptor and slows effect of naturally occuring messenger

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15
Q

Acetylcholine (ACh) receptors

A
  • nicotinic
  • muscarinic
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16
Q

Acetylcholine (ACh) common sites/actions

A
  • neuromuscular junction/excitatory
  • PNS regulation
  • limbic system/arousal
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17
Q

Acetylcholine (ACh) agonists

A
  • nicotine
  • muscarine
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18
Q

Acetylcholine (ACh) antagonists

A
  • curare
  • atropine
  • Botox
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19
Q

Acetylcholine (ACh) clinical applications

A
  • Myasthenia gravis
  • Alzheimer’s
  • smoking
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20
Q

Norepinephrine (NE) receptors

A
  • α1, α2
  • β1, β2
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21
Q

Norepinephrine (NE) common sites/actions

Study These Flashcards
A
  • sympathetic stimulation
  • cortex and limbic system/focus and mood
22
Q

Norepinephrine (NE) agonists

Study These Flashcards
A
  • amphetamines
  • cocaine
23
Q

Norepinephrine (NE) antagonists

24
Q

Norepinephrine (NE) clinical applications

Study These Flashcards
A
  • cardiac (β blockers)
  • panic attacks
25
Dopamine (DA) receptors
D1, D2, D3, D4, D5
26
Dopamine (DA) common sites/actions
- limbic system/pleasure and addiction - basal ganglia/movement and goal directed behavior - frontal lobe/planning
27
Dopamine (DA) agonists
- L-dopa - amphetamines - cocaine
28
Dopamine (DA) antagonists
antipsychotics
29
Dopamine (DA) clinical applications
- drug addiction - Parkinson's disease - ADHD - schizophrenia
30
GABA receptors
- GABA 1 - GABA 2
31
GABA common sites/actions
cerebellum and spinal cord/primary inhibitory transmitter
32
GABA agonists
- benzodiazepines - baclofen
33
GABA clinical applications
Baclofen pumps for spasticity
34
Glutamate receptors
- NMDA - AMPA - kainate
35
Glutamate common sites/actions
CNS/mainly excitatory
36
Glutamate antagonists
phencyclidine
37
Glutamate clinical applications
- excitotoxicity - seizure activity
38
Glycine receptors
glycine
39
Glycine common sites/actions
spinal cord/inhibition
40
Glycine antagonists
strychnine
41
Endorphins (opiods) receptors
μ1, μ2, δ, k1, k2 (G proteins)
42
Endorphins (opiods) common sites/actions
CNS/inhibition of pain signaling
43
Endorphins (opiods) agonists
- opium - morphine - heroin - methadone - fentanyl - hydrocodone - oxycodone
44
Endorphins (opiods) antagonists
naloxone
45
Endorphins (opiods) clinical applications
pain management
46
Serotonin (5-HT) receptors
- 5-HT1 - 5-HT2 - 5-HT3
47
Serotonin (5-HT) common sites/actions
CNS/regulation of sleep, appetite, arousal, pain, perception, and mood
48
Serotonin (5-HT) agonists
antidepressants (reuptake inhibitors)
49
Serotonin (5-HT) clinical applications
- depression - OCD
50
Substance P receptors
NK1
51
Substance P common sites/actions
- mainly excitatory - PNS/pain - CNS/cardiovascular regulation, mood, pain
52
Substance P clinical applications
pathologic pain

ns and behavior (7 decks)

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