Ch 9 Intracellular Signaling Flashcards Preview

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Flashcards in Ch 9 Intracellular Signaling Deck (15):
1

adenylate cyclase

effector enzyme which synthesizes cAMP by converting ATP in G-proteins.

2

How does adenylate cyclase function as a coincidence detector?

AC1 adenylate cyclase is stimulated by neurotransmitters or by a raise in Ca2+. AC2 adenylate cyclases are made only if the Beta section is from an abundant G-protein source.

3

Where is calcium stored in cells?

ER

4

Which enzyme synthesizes cAMP?

adenylate cyclase

5

Which enzyme synthesizes DAG and IP3?

Phospholipase C

6

Which secondary messengers activate protein kinases?

Ca2+, cAMP, DAG

7

What do kinases do?

phosphorylate key intercellular processes

8

Which mediator does Ca2+ activate?

Calmodulin

9

How is cGMP synthesized?

guanylate cyclase synthesizes cGMP from GTP.

10

Why is transducin important?

It is a specialized G-protein activated by photons.

11

The cAMP kinase is...

PKA

12

The cGMP kinase is ...

PKG

13

PI kinase is ...

PKC

14

What are the cognitive kinases?

PKA, PKC, CMKIII

15

What does repetition of PKA stimulation do?

encodes molecular memory so that it is persistently active.