Flashcards in Ch 6 Neurotransmitters Deck (25):
Blocks nerve to muscle signaling by binding to post synaptic acetylcholine receptors.
5 criteria for neurotransmitters
synthesized by neurons. 2. released from nerve terminals in a chemically identifiable form. 3. should reproduce effects in the postsynaptic cell. 4. effects can be blocked by antagonists 5. should be active mechanisms to terminate the action of the neurotransmitter.
5 steps of chemical neurotransmission
1. sythnesis in presynaptic neuron. 2. storage in nerve terminal 3. release into synaptic cleft. 4. Binding and recognition by target cell. 5. termination of action
4 Classical neurotransmitters
catecholamines, serotonin, acetylcholine, GABA
dopamine, norepinephrine, epinephrine
precursors for catecholamines
phenylalanine and tyrosine
how is catecholamine synthesis increased
new TH enzyme protein must be synthesized.
Enzyme L-Aromatic Amino acid Decarboxylase, aka. DOPA decarboxylase.
Vesical monamine transporters, accumulate and release dopamine vesicles
What does the exocytosis of catecholamine require?
Calcium (except in dendrites)
monomine oxidase, an enzyme that terminates catecholamine action.
Catechol-O-methyltransferase, an enzyme that terminates catecholamine action
depletes both seratonin and catecholamines in the brain.
5 hydroxytryptamine (5-HT)
an essential amino acid not made in the body
Coupled with intracellular G proteins as effectors.
Channels that let Na+ and Ca2+ into the neuron.
Found on presynaptic neuron. Part of feedback loop.
Found on axons. Respond to the release of transmitters from a different axon
Terminate neurotransmitter actions
Reuptake, enzymatic degradation, diffusion
Precursors for catecholamine
Tyrosine and phenylalanine
Catecholamines usually refer to the 3 neurotransmitters...
Dopamine, norepinephrine, and epinephrine.
Parkinson's disease is due to a loss of .... And treated with ....
Dopamine, l-DOPA precursor goes in and is metabolized into dopamine.
Vesicular monamine transporters.