Ch 6 Neurotransmitters Flashcards Preview

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Flashcards in Ch 6 Neurotransmitters Deck (25):
1

Curare

Blocks nerve to muscle signaling by binding to post synaptic acetylcholine receptors.

2

5 criteria for neurotransmitters

synthesized by neurons. 2. released from nerve terminals in a chemically identifiable form. 3. should reproduce effects in the postsynaptic cell. 4. effects can be blocked by antagonists 5. should be active mechanisms to terminate the action of the neurotransmitter.

3

5 steps of chemical neurotransmission

1. sythnesis in presynaptic neuron. 2. storage in nerve terminal 3. release into synaptic cleft. 4. Binding and recognition by target cell. 5. termination of action

4

4 Classical neurotransmitters

catecholamines, serotonin, acetylcholine, GABA

5

catecholamines

dopamine, norepinephrine, epinephrine

6

precursors for catecholamines

phenylalanine and tyrosine

7

how is catecholamine synthesis increased

new TH enzyme protein must be synthesized.

8

AADC

Enzyme L-Aromatic Amino acid Decarboxylase, aka. DOPA decarboxylase.

9

VMAT

Vesical monamine transporters, accumulate and release dopamine vesicles

10

What does the exocytosis of catecholamine require?

Calcium (except in dendrites)

11

MAOs

monomine oxidase, an enzyme that terminates catecholamine action.

12

COMTs

Catechol-O-methyltransferase, an enzyme that terminates catecholamine action

13

reserpine

depletes both seratonin and catecholamines in the brain.

14

Serotonin

5 hydroxytryptamine (5-HT)

15

tryptophan

an essential amino acid not made in the body

16

Metabotropic receptors

Coupled with intracellular G proteins as effectors.

17

Ionotropic receptors

Channels that let Na+ and Ca2+ into the neuron.

18

Autoreceptor

Found on presynaptic neuron. Part of feedback loop.

19

Heteroreceptor

Found on axons. Respond to the release of transmitters from a different axon

20

Terminate neurotransmitter actions

Reuptake, enzymatic degradation, diffusion

21

Precursors for catecholamine

Tyrosine and phenylalanine

22

Catecholamines usually refer to the 3 neurotransmitters...

Dopamine, norepinephrine, and epinephrine.

23

Parkinson's disease is due to a loss of .... And treated with ....

Dopamine, l-DOPA precursor goes in and is metabolized into dopamine.

24

VMAT

Vesicular monamine transporters.

25

MAO

Monamine oxidase