Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

MBE3 > Ch31-IntroVirology & phage-with highlights > Flashcards

Ch31-IntroVirology & phage-with highlights Flashcards

1
Q

Viruses

A 
simple organization
• DNA or RNA genome
• unable to reproduce outside of
living cells
• obligate intracellular parasites
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Pandora Virus is

A

Big ass MF virus. 1000nm.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Multicomponent viruses genomes are segmented and the

segments are distributed into separate ……………

A

Mosquito Virus:

Multiple distinct particles required for infection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Cultivation of viruses requires inoculation of

living host cell

A 
suitable animals
• embryonated eggs
• tissue (cell) cultures
– monolayers of animal cells
– plaques
• localized area of cellular destruction and lysis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

cytopathic effects (CPEs)

A

microscopic or macroscopic degenerative changes or

abnormalities in host cells and tissues

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Naked Capsid Virus

A

RNA/DNA + Structural Protien + Enzymes nucleic acid binding proteins=nucleocapsid=Naked capsid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Enveloped protien =

A

Nucleocapsid + Glyco proteins and membrane = Enveloped Virus.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Herpes Shape

A

Isosahedral capsid HSV-1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Capsomers

A

Capsid proteins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Bacteriophage T4 Capsid

A

Isosahedral + Tail

Contains DSDNA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Filamentous Virus

A

Helical Symetry

Protein arranged in monomeric units

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Enveloped Virus’s’s have?

A

Glycoprotien spikes attached to liped bilayer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Example of asymtrical virus?

A

Vaccina Pox
Surrounded by outer membrane and contains core enveloped which envelopes DSDNA which is stabilized by hair pin loop at each end.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Single Stranded Positive Sense Fall under what Groupd of Virus.

A

RNA/Noneveloped

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Single stranded Positive sense RNA is grouped by?

A

Uneveloped RNA Virus and Enveloped

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What to types Virus groups are unique to enveloped RNA type fools

A

Retro Virus and Negative sense single stranded

17
Q

In terms of DNA of virus what nucleic acid characteristic are shared between enveloped and non enveloped types.

A

DS Linear DNA and DS circular DNA

18
Q

Single Stranded linear DNA is unique to what type of virus (enveloped v. nonenveloped)

A

Nonenveloped

19
Q

Virus Replication Steps

A 
adsorption
–penetration and uncoating
–synthesis of viral proteins and nucleic acids
–assembly of virions
–release
20
Q

Adsorption of Virions
• viral surface ____________ and/or _________
mediate attachment to specific host
____________

A

Adsorption of Virions
• viral surface proteins and/or enzymes
mediate attachment to specific host
receptors

21
Q

Penetration and Uncoating

• three mechanisms

A

-injection of nucleic acid
– fusion of envelope with host membrane
– endocytosis

22
Q

Assembly of Virus Capsids

A 
capsid proteins
– encoded by late genes
• assembly of naked viruses
– empty procapsids formed then nucleic acid
inserted
• assembly of enveloped viruses
– in most cases, similar to assembly of naked
viruses
• site of morphogenesis varies
23
Q

Virion Release

• naked viruses

A

usually by lysis of host cell

24
Q

Virion Release

Enveloped Virus

A

formation of envelope and release usually
occur concurrently
• virus-encoded proteins incorporated into host
membrane
• nucleocapsid buds outward and is surrounded
by modified host membrane

25
Q

What are some examples of phage receptors?

A

ToLC, OMPF, LPS and Flagella proteins

26
Q

Phage C1 Viral genome that provide host traits

A

Botulnum Toxin (c1)

27
Q

Beta Phage (corynebacterium diphtheria)

A

Dipotheria Toxin (tox) (corynebacterium diphtheria)

28
Q

Human endogenous Retro Virus

HERV-W

A

Syncytin (retroviral ENV protien) : placental Fusion.

29
Q

HERV-E

A

Apolipoprotein C1 ( facks with liver function)

30
Q

Bacteriophage cylcle slow release

A

Bacteriopahge exit cell without lysis.

Host cell reproduces more slowly because the phage is using the host cells resources (AH).

31
Q

Bacterial Defense against Phages

A

Genetic resistance – mutations in bacterial genes (e.g. receptor)
Restriction endonucleases – enzymes that cut invading DNA
CRISPR – a bacterial immune system

32
Q

CRISPR – a bacterial immune system

A

A piece of phage DNA gets copied into host genome (crispr). Upon reinfection, the crispr is translated and combines with Cas complex which then recognizes and cleaves phage DNA…more or less.

33
Q

Phage therapy being explored as a potential

A

antibiotic treatment

MBE3 (13 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions