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MBE3 > Helicabacter Ch. 18,19,22 > Flashcards

Helicabacter Ch. 18,19,22 Flashcards

1
Q

Helicobacter pylori

A

Vibro

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2
Q

Ureas virulence and associated bacterium

A

Helicobacter pylori urease (urea —> ammonia ^ pH increase, neutralization of stomach acid)

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3
Q

VacA protein virulence and associated bacterium

A

Helicobacter pylori VacA protein acts on gastric mucosal epithelia and promotes flow of urea into stomach

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4
Q

CagA protein virulence and associated bacterium

A

Helicobacter pylori CagA protein: injected into host epithelia > cells change (prelude to cancer)

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5
Q

mucinase

A

Helicobacter pylori mucinase, phospholipase, cytotoxin, LPS ® inflammatory response

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6
Q

Gastric ulcer associated with with

A

Helicobacter pylori

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7
Q

in most people: no symptoms (symptom-free carrier).

A

Helicobacter pylori

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8
Q

Gram−
short rods

A

Pseudomonas aeruginosa

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9
Q

GGram−
short rods
polar flagella (one or more; high mobility)
obligate aerobe
simple nutrient requirements (acetate)
broad temperature range: 20 to 43 ºC

A

Pseudomonas aeruginosa

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10
Q

Alginate

A

Pseudomonas aeruginosa

Biofilm Formation

Adherance/ Protection from dihydration

immune invasion

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11
Q

Lipopolysaccharide

A

Lipid A ins endotoxin

core interacts with CFTR

O antigen protects from complement killing

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12
Q

opportunistic pathogen (in case of disease, cancer, weakened immunity):
1. common in environment (water, soil) +
Hot tubs are perfect culture conditions (due to heat tolerance)
2. resistance to many chemical desinfectants (like iodine) +
3. R-plasmid based resistance to many antibiotics

A

Pseudomonas aeruginosa

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13
Q

major problem in hospitals (nosocomial infections)
ü lungs: artificial ventilators, cystic fibrosis (mucoid strains)
ü skin: burn victims, folliculitis
ü bladder infections
ü ear infections
(swimmer􀀁s ear:
otitis externa)
ü eye infections
(from contact lenses)

A

Pseudomonas aeruginosa

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14
Q

Soluble blue-green dye pyocyanin and
pyoverdin characterize P.aeriginosa

A

Pseudomonas aeruginosa : green burn wounds

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15
Q

Pulmonary CF

A

Pseudomonas aeruginosa

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16
Q

Bordetella pertussis

positive or negative

A

gram -

17
Q

Bordetella pertussis

Shape

A

coccobacilli

18
Q

GGram−
coccobacilli
strict aerobe
non-motile, capsule

A

Bordetella pertussis

19
Q

__________ show dense surface growth in the lower
respiratory tract (bronchi, bronchioli) without cell
invasion and with strong mucus secretion.

A

B.pertussis show dense surface growth in the lower
respiratory tract (bronchi, bronchioli) without cell
invasion and with strong mucus secretion.

20
Q

Whooping cough

A

B.pertussis

21
Q

adhesion to ciliated respiratory tract cells
but NOT invasive

A

􀀂Whooping cough􀀃 (pertussis)
adhesion to ciliated respiratory tract cells
but NOT invasive

22
Q

(ADP-ribosylation of G-protein: cAMP
􀀄
mucusand
other secretions)

A

pertussis toxin ptx
(ADP-ribosylation of G-protein: cAMP
􀀄
mucusand
other secretions)

23
Q

secreted invasive adenylate cyclase / hemolysin =

A

cAMP ^

24
Q

kills ciliated cells
toxin is a component of peptidoglycan
disaccharride-tetrapeptide

A 
tracheal cytotoxin (Nitric Oxide 􀀂NO􀀃 release) 􀀄
kills ciliated cells
toxin is a component of peptidoglycan
disaccharride-tetrapeptide
25
Q

toxin is a component of peptidoglycan
disaccharride-tetrapeptide

A

tracheal cytotoxin (causes Nitric Oxide 􀀁NO􀀂 release)
kills ciliated cells
toxin is a component of peptidoglycan
disaccharride-tetrapeptide
Most gram negative bacteria keep TCT within the cell wall by using a transporter protein to recycle it.
B. pertussis not capable of recycling TCT and it escapes to the surrounding environment.

26
Q

aerosol transmission
children􀀂s disease
(mild symptoms in adults
who are the 􀀁reservoir􀀂)

A

Bordetella pertussis

27
Q

DTaP vaccine

A 
DTaP vaccine (Diphtheria,
Tetanus, acellular Pertussis)
28
Q

Gram+ pleiomorphic (club-shaped) rods

A

Corynebacterium diphtheriae

29
Q

V Shaped

A

Corynebacterium G+ diphtheriae

30
Q

(phage β coded)

A

diptheria

31
Q

pseudomembrane in throat: heart and kidney

A

diptheria toxin

32
Q

inactivates elongation factor EF-2, inhibits protein synthesis.

ribosylation

A

Diptheria toxin

AB component

33
Q

ADP-ribosylation of EF-2
causing translation stop)

A

diphtheria toxin

34
Q

Disease risks from toxin: Dipthelia

A

paralysis
impaired swallowing
peripheral neuritis
• Suffocation (due to blockage)
systemic:
• cardiac arrythmia
• kidney failure

35
Q

Corynebacterium diphteriae spreads via

A

Spread by saliva droplets

36
Q
A

MBE3 (13 decks)

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