Chap-14 Vitamins Flashcards by Danny Dennaoui

Vitamin A :

cycle

good for vision,

Pre-vit.A-> Transport to intestinal cells -> CRBP-II , packed into chylomicrons

How well did you know this?

Not at all

Perfectly

Vitamin D:

Pathway for Liver

D3 (cholecalciferols) and D3 (ergocalciferosl) –> Metabolized to 25 (OH)D3/D2 - In liver using 25(oh)’ase

How well did you know this?

Not at all

Perfectly

Pathway for Kidney (Vit.D)

25 (OH) D3/D2 –> 1,25 (OH)2 D using 25(OH) 1alphaOH’ase - Kidney
1,25 (OH)2 D is biologically active hormone

How well did you know this?

Not at all

Perfectly

What can control vitamin D and Ca (Vit.D)

PTH, Ca , 1,25 (OH) D

How well did you know this?

Not at all

Perfectly

How to Increase synthesis of 1,25 (OH)2 D? (Vit.D)

Inc. PTH and Decrease P

How well did you know this?

Not at all

Perfectly

What does Low Calcium cause? (Vit.D)

Inc. PTH stimulation …

How well did you know this?

Not at all

Perfectly

Increase In Calicum and Increase P. and 1,25(OH)2D (Vit.D)

Decreases the enzyme to make 1,25(OH)2D .

How well did you know this?

Not at all

Perfectly

Increase in PTH, Low Ca and Low P (Vit.D)

Increases 1,25 (OH)2D , increases the enzyme 1,25(OH)D1alphaOH’ase

How well did you know this?

Not at all

Perfectly

Increase Ca, Inc. P and presence of 1,25(OH)2D (Vit.D)

Decrease 1,25(OH)2D and decrease the eznyme to make it

How well did you know this?

Not at all

Perfectly

1,25 (OH)2D causes : (Vit.D)

increase in 24,25(OH)2D which converts teh 1,25 (OH)2 to be inactivated to make calcitroic acid.

How well did you know this?

Not at all

Perfectly

What does 1,25 (OH)2 D do in the duodenum and illeum / jegunum? (Vit.D)

Stim, Ca abs duodenum

Stim P, abs in Jegunum

How well did you know this?

Not at all

Perfectly

3 ways to determine 25(OH)D [ ] (Vit.D)

Look at CaT1 - transporter
Calbindin D9k - diffusion
CaATP’ase - let ca exit

How well did you know this?

Not at all

Perfectly

Vitamin E: impact on ROS?

Anti-oxidant for ROS

How well did you know this?

Not at all

Perfectly

What other vitamin E works with?

Vit.C

How well did you know this?

Not at all

Perfectly

What is vit.E converted to in the liver?

Alpha-Tocopherols using alpha-TPP by VLDL

How well did you know this?

Not at all

Perfectly

alpha tocopherols effects : (vit.E)
-:
+:

‘hibit prot.K C and 5lipoxygenase

+: protein. P’ase 2A and DAG.K

How well did you know this?

Not at all

Perfectly

Vitamin K Used for:

Blood clotting as cofactor to make vit.K carobxylase

How well did you know this?

Not at all

Perfectly

Function of Vit.K carobxylase?

Helps add glutamyl residues to gama-gla, and gama-gla increase affinity to ca2+ binding.. which will make thrombin factors

How well did you know this?

Not at all

Perfectly

Vitamin B1-

Thiamine

How well did you know this?

Not at all

Perfectly

Vit.B1 - is co-enzyme to what?

TPP , which is used to make pyruvate and 2-oxoglutarate in the PDH

How well did you know this?

Not at all

Perfectly

Vit.B1 3 enzymes affect:

Thamine.K (Thiamine + ATP —> TPP + AMP)
TPP-ATP ( TPP + ATP—–> 3P + ADP)
Thaimine Trio-P.’ase (TPP —> M.P)

How well did you know this?

Not at all

Perfectly

TPP Is a coenzyme to > (Vit.B1)

Mg2+ in PDH and Alpha-ketoglutarate dehydrogenase

How well did you know this?

Not at all

Perfectly

What function does Vit.B1 have on cells?

Study These Flashcards

Regulate cl- ion channels and signalling

Defiency to vit.B1

Study These Flashcards

Wernicke-Korsakoff and Berriberri

Vitamin B2->?

Riboflavin

What is riboflavin used for?

FAD and FMN redox reactions

What can stimulate FAD and FMN synthesis?

T3 and T4 hormones

What can Vit.B2 do to homocysteine?

Decreases it because FAD is a co-factor for MTHFR

Vitamin B3-->?

Niacin/Niacademide

What is niacin/ademide used in? B3

To make NAD and NADP+

What can Nicotnic acid do ? B3

It can lower T.G and Inc. HDL

Defiency of B3

Pellagra

Vit.B5 -->?

Panthotenic acid

Vit.B5 2forms:

L-valine (pantoic acid) ; B-alaline (L-asparate)

Role of vit.B5 in TCA?

ACP and -coA in the PDH

Defficiency to vit.b5?

Burning feet

Vit.b6 names?

Pyrodoxine , pyridoxamine ; pyridoxal

What does vit.b6 get ultamadly converted to?

PLP . Pyridoxal phosphate

What will low b6 cause?

Nitrogen stores to be lower and have tryptophan problems

Vit.b7 name

Biotin or vit.H

what is biotin used in?

Carboxylic rxn of pyruvate , Acetyl-coA and propionyl-coA

Fxn of biotin?

GLuconeogenesis Fa synthesis A.A breakdown

Egg relation?

Egg whites = avidin Egg yolk=biotin avidin binds irreversably biotin

Name of B9?

Folic acid

Role of B9

Used to make purines, dTMP , cholines and serines

What is folic acid a co-enzyme for?

Pteroic acid which ataches to glu... forming pte-glu

What does b9 get converted to?

Pte-glu reduced to 5MTHF

Role of methyl-transferase in B9?

5-MTHF --> Cobalmin.. | and methyl-transferase is in similar metabolism of folic acid in b-12 .. because b-12 is cobalmins

B-12 low with B9>>??

B-12 low = body traps the folate here to not be used and to save them.

Deffiency to b9>

Megloblastic anemia

How to derease the homocystein with b9>

Inc.Folate = avoid pathways that makes homocysteine.

Vit.b12 name?

Cyanocobalamin.

Fxn of b12?

Cobalamins are tetrapyroles with a cobalt in the center.

What is a corrin ring?

its the 4 pyrole rings without the cobalt in the center, but still cobalamin

What do we find in serum and in cytosol vit.b12

Methyl-cobalamin in serum | Adenosyl-cobalamin in the cytosol..

How does the body transport b12 food to circulation?

1-Bind haptocorrin 2-B12 free will bind IFthe slow haptocorrin 3- Distal illeum b-12-IF intetraction, will bind a R on mucosal epithelial cells 4-B12 disociates and binds the tc-II in cells 5- Tc-B12 goes bind Tc-B12-R on membranes and released in the blood.

Chap-14 Vitamins Flashcards

(56 cards)