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Flashcards in Chapter 1 Deck (31):
1

Innate Immunity

If bacteria break through barrier certain cells attack and kill

2

Adaptive Immunity

Occurs when bacteria by pass innate immune system
-lymphocytes involved (B and T cells)

3

Difference Between Innate and Adaptive

Innate - Fast, Fixed, Limited # of specificities, Constant during response
Adaptive - slow response, Variable, Highly selective, Improve during response

4

Whats involved in adaptive immunity?

Ab
T-cell recognition
Cell mediated activation of the innate immune response

5

What are Abs?

Serum proteins that result from specific immune response

6

What is the Abs structure?

Have high aff binding sites for specific Ags on one end
On the other end are Fc regions

7

Fc Receptor?

The receptor for Fc regions on effector cells

8

Opsonization

When specific Ab is present - a high affinity bridge if formed enhancing phagocytosis

9

Opsonins

Abs responsible for opsonization

10

Complement System

A group of serum proteins that either recognizes microorganism directly or bind to and recognize bound Ab

11

Job of complement system?

Result in lysis
Result in deposition of complement of the cell surface
C3 can act as an opsonin

12

How are cells defined

Morphological Criteria
Antigenic

13

Morphological Criteria

Size and shape of cell
Size and shape of nucleus

14

Antigenic

A subset of monoclonal Ans that recognize a subset of immune cells
Cluster of Differentiation - CD

15

Neutrophils - PMN leukocytes

Most abundant leukocyte (60-70%)
Circulate in blood only for short time
During inflammation these cells enter tissue and complete their life cycle
Contain granules

16

What are the two major classes of granules in PMNs?

Primary or azurophilic and
Secondary of specific granules
Contain the bactericidal and hydrolytic Ens of cell

17

Neutrophils job

Phagocytosis and killing of microorganisms
Travel to and enter infected tossie - engulf and kill bacteria
The N die in tissue and are engulfed/degraded by MO

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Where are N found?

Stored in BM and are released when needed

19

Eosinophils

1-3 % of circulating leukocytes
Removed from circulation rapidly (1/2 life 30mins)
Can survive up to 12 days in tissue

20

What is EBP?

Eosinophil basic protein - important in clearing parasitic worms

21

Job of eosinophils

Killing of Ab-coated parasites through release of granule content

22

Basophil

Job unknown

23

Macrophages (MO) - Monocytes

Monocytes are derived in BM and circulate the blood and when enter tissue are called MO

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MO job

They are capable of both intra and extra cell killing
Phagocytosis and killing of microorganisms
Activation of T cells and initiation of immune response

25

Dendritic Cells

Activation of T-cells and initiation of adaptive immune responses

26

Mast Cells

Expulsion of parasites from body through release of granules containing histamine and other active agents

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Lymphocytes

T and B cells

28

B lymphocyte

A small lymphocyte that expresses Ig on its surface
Produces Abs

29

T-lymphocyte

Critical cell in regulating immune responses as well as the effector function of killing infected cells

30

Cytotoxic T-cell

Play and imp role in the regulation of the immune response as well as act as an effector cell
Have CD8 cell surface marker
Recognition of target cell is mediated via a specific receptor and the process is called Ag specific

31

NK cells

Large granular lymphocytes
Kill tumor and infected cells w/o apparent specificity