Flashcards in Immunodeficiency Deck (16):
What are the four limbs of the immune system? (C,H,C,P)
What is the distribution of Primary Immunodeficiencies?
What is a disease brought on by problems with phagocytes?
Chronic Granulomatous DIsease (CGD)
What occurs in CGD?
It is NOT loss of phagocytes, just loss of SPECIFIC function
What is a disease brought on by a COMBINED IMMUNODEFICIENCY?
What is the reason for X-linked SCID?
There is a defect in IL2 gamma chain (signals transduce through this chain) - FUNCTIONS ARE LOST
They are usually prone to EVERY TYPE of infection
-so needs to be treated aggressively
What is a disease brought on by HUMORAL IMMUNODEFICIENCY?
Bronchiectasis - Damage to airways and causes them to widen and become flabby and scarred
How to determine person has this?
History and X-ray findings
Can you give vaccines to these people?
Yes, but NOT live vaccines
**What is a disease brought on by HUMORAL IMMUNODEFICIENCY?
What is X-linked Agammaglobulinemia
-Absence of BCs due to mutations in BTK
-CD40 ligand deficiency
-->plenty of IgM but not IgG
-->no germinal centers
**What is a disease brought on by CELLULAR IMMUNODEFICIENCY?
-Lack of thymus
Often given Ab – w/o T-cells they don’t help B-cells and cant make Ab
**What is a disease brought on by COMPLEMENT IMMUNODEFICIENCY?
-deficiency in C8
Can they receive vaccines?
This child load up with vaccines
Can receive live vaccines (T and B cells are normal)