Immunodeficiency Flashcards Preview

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Flashcards in Immunodeficiency Deck (16):
1

What are the four limbs of the immune system? (C,H,C,P)

Cellular Immunity
Humoral Immunity
Complement
Phagocytes

2

What is the distribution of Primary Immunodeficiencies?

Humoral Immunity
Phagocyte
Cellular
Complement
Combined

3

What is a disease brought on by problems with phagocytes?

Chronic Granulomatous DIsease (CGD)

4

What occurs in CGD?

It is NOT loss of phagocytes, just loss of SPECIFIC function

5

What is a disease brought on by a COMBINED IMMUNODEFICIENCY?

X-linked SCID

6

What is the reason for X-linked SCID?

There is a defect in IL2 gamma chain (signals transduce through this chain) - FUNCTIONS ARE LOST

7

Treatment?

They are usually prone to EVERY TYPE of infection
-so needs to be treated aggressively
-need transplant

8

What is a disease brought on by HUMORAL IMMUNODEFICIENCY?

Bronchiectasis - Damage to airways and causes them to widen and become flabby and scarred

9

How to determine person has this?

History and X-ray findings
B-cell enumeration
Quantitative Igs

10

Can you give vaccines to these people?

Yes, but NOT live vaccines

11

**What is a disease brought on by HUMORAL IMMUNODEFICIENCY?

X-linked Agammaglobulinemia

12

What is X-linked Agammaglobulinemia

-Absence of BCs due to mutations in BTK
-CD40 ligand deficiency
-->plenty of IgM but not IgG
-->no germinal centers

13

**What is a disease brought on by CELLULAR IMMUNODEFICIENCY?

DiGeorge Syndrom
-Lack of thymus
Often given Ab – w/o T-cells they don’t help B-cells and cant make Ab

14

**What is a disease brought on by COMPLEMENT IMMUNODEFICIENCY?

Meningitis
-deficiency in C8

15

Can they receive vaccines?

This child load up with vaccines
Can receive live vaccines (T and B cells are normal)

16

**Consequences of phagocyte immunodificiency?

Phagocytes can not kill normally
**Usual bacteria that run and UNUSUAL course, or UNUSUAL bacteria