Flashcards in Chapter 1. Cell Injury - Intracellular Accumulations Deck (4)
how does fatty change in the liver come about?
cytosolic accumulation of TG, usually packaged in VLDL fraction
-increased TG synthesis occurs with increased conversion of DHAP to G3P, then adding 3 FA
--increased NADH production from alcohol increases conversion
-increased CHO intake increases DHAP
-decreased packaging of TG into VLDL and secretion of VLDL into plasm aby apo B-100
what is the morophology of fatty liver?
normal or enlarged liver with yellowish discoloration
-clear space pushing nucleus to periphery
-fatty change may also occur in cardiac muscle from severe anemia, diphtheria (exotoxin inhibits beta-oxidation of FA) to give mottled appearance ("tabby cat or thrush heart")
what is dystrophic calcification?
calcification of necrotic tissue, with normal serum calcium and phosphate