Chapter 1. Cell Injury - Intracellular Accumulations Flashcards Preview

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Flashcards in Chapter 1. Cell Injury - Intracellular Accumulations Deck (4)
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1

how does fatty change in the liver come about?

cytosolic accumulation of TG, usually packaged in VLDL fraction
-increased TG synthesis occurs with increased conversion of DHAP to G3P, then adding 3 FA
--increased NADH production from alcohol increases conversion
-increased CHO intake increases DHAP
-decreased packaging of TG into VLDL and secretion of VLDL into plasm aby apo B-100

2

what is the morophology of fatty liver?

normal or enlarged liver with yellowish discoloration
-clear space pushing nucleus to periphery
-fatty change may also occur in cardiac muscle from severe anemia, diphtheria (exotoxin inhibits beta-oxidation of FA) to give mottled appearance ("tabby cat or thrush heart")

3

what is dystrophic calcification?

calcification of necrotic tissue, with normal serum calcium and phosphate

4

what is metastatic calcification?

calcification of normal tissue, due to increased serum calcium and/or phosphate