Chapter 14 Flashcards
a heritable change in the genetic material
Mutation
affects only a single base pair within the DNA
Point Mutation
A specific type of point mutation in which one base has been replaced by another base.
Base substitution mutation.
Mutations that do not alter the amino acid sequence
Silent Mutation
a base substitution that changes a single amino acid in a polypeptide sequence.
Missense Mutation
involves a change from a normal codon to a stop codon.
Nonsense Mutation
an addition of deletion of nucleotides that are not in multiples of three
Frameshift mutation
Mutations that can be passed on to offspring through gametes (egg and sperm)
Germ line
Mutation that cannot be passed on to offspring, occur in what type of cell
Somatic Cells (all cells in the body except germ line)
Mutations that result from abnormalities in biological processes
Spontaneous Mutation
Mutations that are caused by environmental agents
Induced Mutation
These environmental agents
Mutagen
the result of mutations that cause overly high levels of expression.
Oncogene
Mutations which result in inactivity of this gene and cancer may occur
Tumor-Suppressor Gene
A normal gene, that if mutated, can become an oncogene.
Proto-oncogene