Chapter 14 Flashcards
(18 cards)
Walter Reed
studied foot-and-mouth disease and yellow fever
herpesviridae
double stranded DNA virus icosahedral symmetry enveloped large - 150-200nm causes cold sores, genital herpes, chickenpox, shingles, mononucleosis
hepadnaviridae
double stranded DNA virus with RNA intermediate
icosahedral symmetry
enveloped
causes hep B, liver cancer
parvoviridae
single stranded DNA virus (the only one) icosahedral symmetry naked small - 18-26nm causes fifth disease, gastroenteritis
coronaviridae
single stranded + RNA virus
helical symmetry
enveloped
causes SARS
orthomyxoviridae
single stranded - RNA virus
helical symmetry
enveloped
causes influenza
retroviridae
single stranded + RNA with DNA intermediate
icosahedral symmetry
enveloped
causes AIDS, T-cell leukemia
HIV virus tissue tropism
CD4+ T cells and macrophages
Epstein-Barr virus tissue tropism
B cells
influenza A virus cell surface receptor
sialic acid cell surface receptors
HIV-1 virus cell surface receptor
CD4 cell surface receptors + co-receptors
three modes of action of antiviral agents
penetration/uncoating inhibitors
genome replication inhibitors (base analogs)
maturation/release inhibitors
cytopathic effects (CPEs)
noticeable changes to host cells when viruses replicate within them
two types of cytopathic effects
changes in cell structure
cell inclusions
cancers caused by Epstein-Barr virus
Burkitt lymphoma
Hodgkin lymphoma
cancer caused by human papilloma virus
cervical, penile, and oropharyngeal cancer
cancer caused by herpesvirus 8
Kaposi’s sarcoma
cancer caused by hep B and C viruses
liver cancer
hep C is an RNA virus
