Chapter 16 - Renal Impairment

Question 1

total body clearance is described as ___ + ____

Answer 1

renal + nonrenal clearance

Question 2

if a drug is 100% nonrenally cleared, does it really matter if the patient has kidney failure?

Answer 2

NO
wont affect clearance at all. only nonrenal

Question 3

true or false

Vd is dependent on kidney function

Answer 3

FALSE - independent

Question 4

if m = 0.25, how much of the drug is removed by the kidney and how much is not?

Answer 4

25% removed by kidney

75% not

Question 5

true or false

a creatinine clearance of 100mL/min indicates a normal, healthy kidney

Answer 5

true

Question 6

3 potential options for dose adjustment in the renally impaired

is one preferred over the other?

Answer 6

all are equal

can change dose and maintain dosing interval

can keep dose and change dosing interval

can adjust both the dose and the interval