Chapter 17 - Therapeutic Drug Monitoring

Question 1

the plasma concentration in the patient is theoretically correct, but the patient is still not responding to therapy

name 2 reasons this could be

Answer 1

-drug interaction at the receptor site

-tolerance (altered sensitivity)

Question 2

true or false

a rapid rate of drug elimination could result in plasma concentrations that are higher than anticipated

Answer 2

false - lowe

Question 3

giving a CONTROLLED or SLOW release tablet instead of immediate release would result in plasma concentrations _______ than anticipated

Answer 3

lower

Question 4

true or false

an enlarged volume of distribution would result in plasma concentrations higher than anticipated

Answer 4

false - lower

Question 5

true or false

a slow rate of drug elimination would result in plasma concentrations HIGHER than expected

Answer 5

true

more accumulation
a reason could be due to kidney failure

Question 6

when steady state is not reached, this could result in ______ plasma drug concentrations than expected

Answer 6

lower