Chapter 18 - Non-Compartmental Methods Flashcards
(19 cards)
a STATISTICAL method to calculate ADME
non-compartment methods
a simplified, kinetic approach to describe ADME
compartment models
why are non compartment methods becoming more popular
the simplicity and flexibility
can have a wide application
non-compartment models use the ____ curve
moment curve
in statistics what are the 2 parameters used most frequently? thus, they are the basis of non-compartment models
mean and standard deviation
true or false
it is not possible for 2 sets of data to have the same mean, but a VERY DIFFERENT standard deviation
false- it is very possible
the moment curve is ____ vs ____
Ctn vs t
as mentioned, the moment curve is Ctn vs t
what happens if n=0,1, or 2
if 0 - zero moment curve
if 1 - 1st moment curve
if 2 - 2nd moment curve
explain what MRT (mean residence time) means
the average residence time of the drug molecules in the body
mean residence time after IV bolus follows what?
instantaneous administration
all of the molecules start their residence time at the SAME TIME and at time infinity they are essentially all eliminated
how to find the MRT for instantaneous administration (ie - IV bolus)
divide the total residence time for all of the drug molecules/the total number of molecules adminstered
true or false
the MRT for non-instantaneous administration is always higher (longer) than the MRT for instantaneous
TRUE
bc the drug spends extra time at the site of administration (ie - GI tract, subq tissue, muscle)
true or false
higher Ka means longer time to absorb
true
true or false
continuous infusion is considered non-instantaneous administration
true
name the 3 methods of determining MRT after IV bolus injection
-from the 1st moment curve
-from elimination rate constant
-by the area method (from AUC)
**as mentioned, one method of finding MRT after IV bolus injection is through the 1st moment curve
what is the formula?
MRT = AUMC/AUC
MAT (mean absorption time) is the average time for…..
all the drug molecules to be ABSORBED from the site of administration
true or false
for the same drug, the K can change depending on the route of administration
FALSE - does not change regardless of the route of administration
