Chapter 16 Study Questions (Pt. 2) Flashcards
what ion channels are primarily responsible for maintaining respiratory tract hydration? (5)
a. CFTR channels
b. Na+/K+/2Cl- symporters
c. Na+/K+ ATPases
d. K+ leak channels
e. ENaCs
what is the role of CF channels?
move Cl- into the lumen
how to open/close the CFTR gate?
open: ATP must bind to open the gate
close: gate closes when CFTR hydrolyzes ATP
how does Cl- move through a CF channel?
on a concentration gradient
on which membrane is this found: ENaC
apical
on which membrane is this found: CFTR
apical
on which membrane is this found: Cl-
apical
on which membrane is this found: aquaporin
apical and basolateral
on which membrane is this found: K+ leak channel
basolateral
on which membrane is this found: Na/K ATPase
basolateral
on which membrane is this found: sodium/potassium/2Cl
basolateral
how is excess Na+ removed from the cell?
Na+/K+ ATPases remove excess sodium
how is excess potassium removed from the cell?
K+ leaks out through potassium leak channels
how does water get into the airway lumen?
if no functional CF channels = Na enters lung epithelial cells = water pulled from airway lumen and mucus
what is the name of the process where water leaves the lumen?
absorption
