Chapter 16- The Endocrine System Flashcards
(49 cards)
Hormones
Long distance (not affecting the cells that are in the same tissue they are inchemical messengers that cause a change in metabolic activity of a cell
long lasting
hormone control
Reproduction
Growth and development
Immune system activation
Maintenance of various blood components (glucose, electrolytes, water, etc.)
autocrines and paractines
short-sdistance chemical messengers
more localized infections
autocrine
a chemical message that affects the same cell that produces the message
paracrine
a chemical message that is produced by one cell but affects a different cell
same tissue but different cell
Major classifications of hormones
- amino acid-based hormones- water soluble transports a protein from point a to point b
- steroid hormones- synthesized from cholesterol
lipid soluble
the only steroid hormones in the body are gonadal hormones and adrenocortical
Hormone Actions
- Altering plasma membrane permeability or membrane potential (epinephrine)
- stimulates the synthesis of enzymes/proteins in the cell
- Activates and deactivates enzymes
- induces secratory activity
- stimulates mitosis
Target cells
affected by hormones that have the appropriate receptor
2 mechanisms of hormones
- secondary messenger system through g protein (extremely efficient)
- intracellular system- hormone enters cell and binds to intracellular receptors and DNA transcription occurs
stimulus mechanisms
- humoral stimuli- change blood levels of critical ion and nutritns
- neural stimuli- nerve fibers stimulate hormone release
- hormonal stimuli- hormone released in response to other hormones
hormone concentration in blood depends on
- how fast its released from the organ
- how fast it is broken down (hormones are removed by kidneys and liver) (water soluble hormones have shortest half life)
Hormone release
negative feedback mechanism
activation of a cell depends on
- blood levels of a hormone (more blood = more binding)
- number of receptors for specific hormone on/in a cell (more receptors = more binding)
- affinity of receptor to the hormone (easier binding, the higher the effect)
up-regulation
increase receptor number in response to low hormone levels
down-regulation
decrease receptor number in response to high hormone levels (safety backup mechanism)
Permissiveness
one horone cannot have funn effect without binding of a second specific hormone
synergism
2 or more horones with similar effects bind to target cell and amplification occurs
antagoism
one hormone opposes the effect of another and they will compete
Pituitary gland
anterior and posterior pituitary
anterior pituitary
manufacturers and releases several dfifferent hormones
posterior pituitary
composed mostly of neural tissue and nerve fibers
release of hormones controlled by pituitary
- action potentials from hypothalamus causes hormone release (posterior pituitary)
- hypothalamic hormones released into hypophyseal portal system (anterior pituitary)
hypophyseal portal system
stimulate or inhibit hormone release
Oxytocin
stimulant for uterine contraction, milk ejection, “cuddle hormone”
Neurotransmitter in brain → promotes nurturing, couple bonding, trust, affectionate behavior
Stretching of cervix during childbirth sends afferent impulses to hypothalamus → stimulates posterior pituitary to release oxytocin