Chapter 23 (1)

Question 1

_______ is a loss of keratinocyte adhesion

_______ is intracellular epidermal edema

Answer 1

acanthylysis

spongiosis

Question 2

URTICARIA (hives) is a type I hypersensitivity & is either IgE-______ from pollen, food, venom, or IgE-______, from ADR’s like opiates, antibiotics etc

Answer 2

dependent

independent

Question 3

Urticaria has wheals that MC fade w/i 24h, and is MC dx in patients ______ years old

Answer 3

20-40

Question 4

• Subcategory of URTICARIA that causes massive dermal swelling due to an inherited C1 ESTERASE INHIBITORY DEFICIENCY from an increased complement system activation
• MC affects pharynx

Answer 4

hereditary angioedema

Question 5

Broad category of cond that all share symptoms of: red, papulovesicular, oozing/crusted lesions

Answer 5

acute eczematous dermatitis (eczema)

Question 6

ECZEMA can be hypersensitivity caused by either type _____ (delayed) or type _____ (allergy) and presents with itchy plaques, EDEMA, but with chronic exposure to the antigen will become _____

Answer 6

IV
I
hyperkeratotic (scaly)

Question 7

MC subtype of ECZEMA, common in infants, TYPE IV hypersensitivity, LIMITED TO CONTACT SITE and is a lifelong pathology

Answer 7

allergic contact dermatitis

Question 8

Subcategory of ECZEMA w/ strong genetic link (80% IDENTICAL TWINS) with a childhood onset of CHRONIC, RELAPSING, PRURITIC lesions that improve with age

Answer 8

atopic dermatitis

Question 9

THREE symptoms that are seen in the ATOPIC TRIAD, associated with several HYPERSENSITIVITIES

Answer 9

dermatitis
asthma
allergic rhinitis

Question 10

Skin disorders whose name refers to a wide variety of appearances, is a TYPE IV HYPERSENSITIVITY, and is either INFECTIOUS (HSV, fungi) or due from ADRs like ASPIRIN

Answer 10

erythema multiforme

Question 11

Characteristic RED MACULE with an eroded or pale vesicular center, seen in erythema multiforme

Answer 11

targetoid

Question 12

Lesions seen in ERYTHEMA MULTIFORME have ________ & ________ crusts, and if from ADRs can be found ANYWHERE.
- Secondary infxn are common and put pt at risk for sepsis

Answer 12

erosive

hemorrhagic

Question 13

ERYTHEMA MULTIFORME is termed _______ when there are milder symptoms POST-INFECTION (MC hsv)

Termed ______ when it is from ADRs, as it causes severe epidermal damage

Answer 13

minor

major

Question 14

LESS severe but life threatening ERYTHEMA MULTIFORME MAJOR, MC IDIOPATHIC but also from ADRs

Answer 14

stevens johnson syndrome

Question 15

MORE severe and life threatening ERYTHEMA MULTIFORME MAJOR that affects >30% of the body and is less common

Answer 15

toxic epidermal necrolysis

Question 16

Group of persistent conditions lasting from months to years with SCALE formation, ROUGH texture

Answer 16

chronic inflammatory dermatoses

Question 17

______ is very COMMON, is in 1-2% of the US population, is pruritic, and is usually from unknown antigens

Answer 17

psoriasis

Question 18

_______ is described as having WELL-DEMARCATED, PINK TO SALMON COLORED PLAQUE COVERED BY LOOSELY ADHERENT SILVER-WHITE SCALE

Answer 18

psoriasis

Question 19

PSORIASIS has _____ cells CD4+ & CD8+ produce GFs that increase kertinocyte growth

Answer 19

T cells

Question 20

UNREGULATED INFLAMMATION from local trauma in PSORIASIS in a linear pattern is called ____________, while _________ sign refers to multiple bleeding points when scale is scraped off

Answer 20

koebner phenomenon

auspitz

Question 21

6 p’s of LICHEN PLANUS

Answer 21

pruritic
purple
polygonal
planar
papules
plaques

Question 22

LICHEN PLANUS shows T cells in the ______________ and while uncommon, is MC in:

Answer 22

dermoepidermal junction

middle aged adults

Question 23

• Lesions of LICHEN PLANUS are SYMMETRICAL, itchy, and if white dots/lines are called ________
• Symptoms resolve in 1-2 years SPONTANEOUSLY

Answer 23

wickham’s striae

Question 24

Idiopathic (but strongly rel to repetitive trauma), ROUGHENED SKIN with DERMAL SCARRING that may accompany ECZEMA or PSORIASIS is _________

Answer 24

lichen simplex chronicus

Question 25

Pre-malignant condition that is a DDx for LICHEN SIMPLEX CHRONICUS

Answer 25

actinic keratosis

Question 26

Common bact infx in children/athletes caused by STAPH AUREUS or STREP PYOGENES that presents lesions with HONEY COLORED CRUSTS

Answer 26

impetigo

Question 27

_______ infections (MYCOSIS), dermatophytosis (RINGWORM) can range from superficial to deep or systemic, which have posses GRANULOMA FORMATION

Answer 27

fungal

Question 28

Invasive ASPERGILLOSIS is ANGIOINVASIVE and can be aggressive, and is caused by

Answer 28

aspergillus fumigatus

Question 29

Tinea ________ is found on the NAILS Tinea _______ is a FOLLICULITIS of the BEARD Tinea ________ is found on NON-HAIRY SKIN TISSUE

Answer 29

unguium barbae corporis

Question 30

_______ are MC affected by VERRUCAE, which are from promoted epi growth, secondary to HPV infxn, MC HPV ________ & ________

Answer 30

pediatrics 6 11

Question 31

VERRUCA ________ is the MC type of WART, is gray white or tan on dorsal hand & PERIUNGUAL regions and is PEBBLE LIKE VERRUCA _______ is FLAT & SMOOTH and is on FACE or dorsal hand

Answer 31

vulgaris | planus

Question 32

BULLOUS disorder may be secondary to other conditions but primary disorder have characteristic separation at specific ________

Answer 32

skin layers

Question 33

Rare, autoimmune bullous d/o seen in MC middle age/elderly resulting from a TYPE II HYPERSENSITIVITY & *IgG* autoantibodies that immunofluoresce with a FISHNET PATTERN

Answer 33

pemphigus

Question 34

Pemphigus _______ is MC and SUPRABASAL, in the MUCOUS MEMBRANES and skin while pemphigus ________ is SUBCORNEAL and RARE, LESS aggressive, and limited to skin

Answer 34

vulgaris | foliaceus

Question 35

__________ is an autoimmune TYPE II HYPERSENSITIVITY of SUBEPIDERMAL blisters, "tense bullae", MC in ___________

Answer 35

bullous pemphigoid | older adults

Question 36

BULLOUS PEMPHIGOID shows linear IgG & complement, lymphocytes & neutrophils in the epidermal __________

Answer 36

basement membrane

Question 37

________ is a rare autoimmune condition, 80% of cases have CELIAC DISEASE, shows with pruritis, vesicles, urticaria on DORSAL ELBOW

Answer 37

dermatitis herpetiformis

Question 38

A skin biopsy showing *IgA* ANTIBODIES in the DERMAL PAPILLAE is seen for a dx of:

Answer 38

dermatitis herpetiformis