Chapter 23 (2) Flashcards
(27 cards)
BENIGN tumor of keratinocytes with FLAT, ROUND “COIN LIKE” PLAQUES for lesions, MC in MIDDLE AGED or ELDERLY and may be very numerous
seborrheic keratosis
With numerous SEBORRHEIC KERATOSIS there is possible paraneoplastic syndrome, which is known by the _________ sign, an explosive onset
leser-trelat
The velvety, granular, or scaly appearance of SEBORRHEIC KERATOSIS mimics which aggressive condition
malignant melanoma
Rare BENIGN skin condition with FLESH COLORED PAPULE that are SLOW GROWING, MC in older adults in head & neck regions
sebaceous adenoma
- Dysplasia precedes EPIDERMAL CA in _______, which is from UV light and presents with tan, brown, red “SANDPAPER LIKE” lesions
actinic keratosis
ACTINIC KERATOSIS is very common, found in ________ % of US adults
11-26%
- AKA LIVER SPOTS, ________ is from HYPERPLASIA of MELANOCYTES from PROLONGED UV EXPOSURE from aging
- Cosmetic concern, but MAY DISGUISE CA
solar lentigo
Sun related skin changes from cumulative UVA & UVB exposure either natural or synthetic - AKA PHOTO-AGING
dermatoheliosis
__________ is from INCREASED SUN EXPOSURE over a lifetime, in OLDER ADULTS, potentially from TAR/OIL or ARSENIC exposure
squamous cell carcinoma
2nd MC skin CA
Squamous cell carcinoma arises from ________, and has WELL DEFINED LESIONS, SCALING DARK BORWN/RED and is not very aggressive
actinic keratoses
If SCC results from burn scars, ulcers, or are in non sun exposed regions, the CA is less
predictable
MC form of skin CA WORLDWIDE, arises from high overall sun/UV exposure and mutated TSGs such as the PTCH gene which has an impact on the HEDGEHOG PATHWAY
basal cell carcinoma
In BCC, the cells RESEMBLE NORMAL BASAL cells but the lesions resemble _________, and if advanced can cause ulceration following severe neglect
(BASAL CELL CARCINOMA)
pearly papules
Within 5 years of BCC removal, 40% of individuals develop:
2nd BCC
Transformed DENDRITIC MELANOCYTES that are tan-brown, uniform pigment, round, solid, well-defined margins
- “BEAUTY MARK”
common nevus
A _______ nevus is a lesion that is >5mm, irreg borders, flat macules or slightly raised plaques with variable pigmentation
dysplastic
________ dysplastic nevus has a LOW risk for melanoma, while _________ type has a 100% lifetime incidence of melanoma (HIGH RISK), and is considered premalignant with >10 lesions
sporadic
familial
- 3rd MC skin CA that is small and aggressive, can be lethal and is MC asymptomatic with some pruritis, but is MC dx in early stages
- INTENSE sunlight exposure (bad burn), DYSPLASTIC NEVI are risks
melanoma
Melanoma grows first _______ and then has _______ growth, which is a measure of mets risk
horizontal
vertical
When advanced, melanoma can mets to lymph &/or blood, MC to these 3 areas
liver
lungs
brain
INCREASED SIZE or CHANGE in COLOR, new lesions in adulthood, or highly dark pigmentation indicates increased _________ in melanoma
agressiveness
ABCD of melanoma
asymmetry
border
color (Most IMPORTANT)
diameter (size-Most IMPORTANT)
First to third MC skin cancers
BCC
SCC
malignant melanoma
_______ is known as the GREAT IMITATOR due to is system wide affects, but also presents with a MALAR RASH
SLE
