Chapter 26 Phatho

Question 1

1. What interstitial lung disease also goes by?

Answer 1

ILD, diffuse interstitial lung disease, fibrotic interstitial lung disease, pulmonary fibrosis, pneumoconiosis.

Question 2

2. ILD refers to?

Answer 2

a broad group of inflammatory lung disorders

Question 3

3. ILD can be?

Answer 3

acute, subacute, or chronic inflammatory inflammatory infiltration of alveolar walls by cells, fluid, and connective tissue

Question 4

4. If ILD is left untreated it can develop into

Answer 4

irreversible pulmonary fibrosis.

Question 5

5. Anatomic alteration of the lungs w/ ILD?

Answer 5

1. destruction of the AC membrane
2. fibrotic thickening of the respiratory bronchioles, alveolar ducts, and alveoli.
3. granulomas
4. honeycombing and cavity formation
5. fibrocalcific pleural plaques - mainly from asbestosis
6. bronchospasm
7. excessive bronchial secretions , caused by inflammation

Question 6

6. Groups of ILD etiology

Answer 6

1. occupational/environmental
2. connective tissue disease
3. idiopathic interstitial pneumonia
4. specific pathology
5. miscellaneous

Question 7

7. What are the Pathologic or Structural changes?

Answer 7

• Destruction of the alveoli and adjacent pulmonary capillaries? in Exam
• Fibrotic thickening of the respiratory bronchioles, alveolar dusts, and alveoli? in Exam
• Granulomas
• Honeycombing or cavitation formation.
• Fibrocalcific pleural plaques (asbestosis)
• Bronchospasm.
• Excessive bronchial secretions (Inflammation in airways
  only)

Question 8

8. What are the Etiology and Epidemiology?

Interstitial lung Diseases of known causes or Associations:

Answer 8

Occupational, Environmental, and Therapeutic Exposures:-

• Inorganic particulate dust exposure.
• Coal dust
• Silicosis
• Beryllium
• Organic material exposure.
• Medications and illicit drugs
• Radiation therapy.

Question 9

9. What is the SYSTEMIC DISEASES?

Answer 9

Connective Tissue Diseases (Collagen Vascular)

• Scleroderma
• Rheumatoid arthritis
• Sjogren’s syndrome
• Polymyotis-dermatomyositis.
• Systemic lupus erthematosus.
• Sarcoidosis.

Question 10

10. What are Idiophathic Interstitial Pneumonias?

Answer 10

• Idiopathic Pulmonary fibrosis.
• Cryptogenic Organizing Pneumonia.
• Lymphocytic Interstital Pneumonia

Question 11

11. What is the Specific Pathology?

Answer 11

• Lymphangioleiomyomatosis (LAM)
• Pulmonary Langerhans Cell Histiocytosis.
• Pulmonary Alveolar Proteinosis.
• Pulmonary Vasculitides.
  . Wegener’s granulomatosis
  . Churg-Strauss syndrome.
  . Lymphomatoid granulomatosis

Question 12

12. What is Miscellaneous Diffuse Interstitial Lung Diseases?

Answer 12

• Goodpasture’s Syndrome
• Idiopathic Pulmonary Hemosiderosis.
• Chronic Eosinophilic Pneumonia

Question 13

14. What is General Management of Interstitial Lung Disease?

Answer 13

• Corticosteroids
• O2 Therapy
• Mechanical ventilation
• Plasmaphereis (Goodpasture’s Syndrome)