chapter 3 Flashcards

(55 cards)

1
Q

What is the cell theory?

A

A cell is the structural and functional unit of life.

It states that all living organisms are composed of cells, and all cells arise from preexisting cells.

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2
Q

What determines the biochemical functions of cells?

A

The shape of the cell and specific subcellular structures.

Structure and function are complementary in cells.

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3
Q

How many different types of human cells are there?

A

Over 250 different types.

These types differ in size, shape, and subcellular components.

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4
Q

What are the three basic parts of human cells?

A
  • Plasma membrane
  • Cytoplasm
  • Nucleus
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5
Q

What are extracellular materials?

A

Substances found outside cells.

This includes extracellular fluids, cellular secretions, and extracellular matrix.

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6
Q

What is the function of the plasma membrane?

A

Acts as an active barrier separating intracellular fluid from extracellular fluid.

It controls what enters and leaves the cell.

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7
Q

What model describes the structure of the plasma membrane?

A

Fluid mosaic model.

It illustrates the flexible lipid bilayer and the arrangement of proteins within it.

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8
Q

What is glycocalyx?

A

Sugars (carbohydrates) sticking out of the cell surface.

It functions as specific biological markers for cell-to-cell recognition.

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9
Q

What are the main components of the lipid bilayer?

A
  • 75% phospholipids
  • 5% glycolipids
  • 20% cholesterol
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10
Q

What are the two types of membrane proteins?

A
  • Integral proteins
  • Peripheral proteins
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11
Q

What characterizes integral proteins?

A

Firmly inserted into the membrane and most are transmembrane proteins.

They have both hydrophobic and hydrophilic regions.

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12
Q

What are the functions of peripheral proteins?

A
  • Enzymes
  • Motor proteins
  • Cell-to-cell connections
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13
Q

What are tight junctions?

A

Integral proteins on adjacent cells fuse to form an impermeable junction.

They prevent fluids and most molecules from moving between cells.

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14
Q

What are desmosomes?

A

Rivet-like cell junctions formed by linker proteins interlocking.

They allow ‘give’ between cells, reducing the possibility of tearing under tension.

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15
Q

What are gap junctions?

A

Transmembrane proteins form tunnels allowing small molecules to pass between cells.

They are used to spread ions and electrical signals quickly.

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16
Q

What are the two essential ways substances cross the plasma membrane?

A
  • Passive transport
  • Active transport
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17
Q

What is passive transport?

A

Movement of substances across the plasma membrane without energy input.

Types include simple diffusion, facilitated diffusion, and osmosis.

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18
Q

What factors influence the speed of diffusion?

A
  • Concentration
  • Molecular Size
  • Temperature
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19
Q

What is simple diffusion?

A

Passive diffusion of lipid-soluble and nonpolar substances through the membrane.

Examples include oxygen and carbon dioxide.

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20
Q

What is facilitated diffusion?

A

Transport of certain molecules down their concentration gradient via carrier or channel proteins.

It applies to hydrophobic molecules like glucose.

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21
Q

What is osmosis?

A

Movement of solvent (e.g., water) across a selectively permeable membrane.

Water moves from areas of low solute concentration to high solute concentration.

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22
Q

What is tonicity?

A

Ability of a solution to change the shape or tone of cells by altering their internal water volume.

Solutions can be isotonic, hypertonic, or hypotonic.

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23
Q

What happens in a hypertonic solution?

A

Water flows out of the cell, resulting in cell shrinking (crenation).

This occurs because the solution has a higher osmolarity than the cell.

24
Q

What happens in a hypotonic solution?

A

Water flows into the cell, resulting in cell swelling and potentially bursting (lysing).

This occurs because the solution has a lower osmolarity than the cell.

25
What happens when osmolarity is lower outside the cell than inside?
Water flows into the cell, resulting in cell swelling. ## Footnote This can lead to cell bursting, referred to as lysing.
26
How is osmolarity calculated?
Osmolarity is equal to molarity times the number of ions (particles). ## Footnote Example: NaCl ionizes to Na+ and Cl−, making 1 M NaCl equal to 2 Osmoles.
27
What is the unit of measurement for osmolarity?
Osmolarity is expressed in osmoles/liter (osmol/L).
28
What are the two major active membrane transport processes?
Active transport and vesicular transport.
29
What do active transport processes require to move solutes?
ATP.
30
What are the reasons active transport is needed?
* Solute is too large for channels * Solute is not lipid soluble * Solute cannot move down concentration gradient
31
What do carrier proteins in active transport do?
They bind specifically and reversibly with the substance being moved.
32
What is an antiporter?
A type of carrier that transports one substance into the cell while transporting a different substance out.
33
What is a symporter?
A type of carrier that transports two different substances in the same direction.
34
What is the primary function of primary active transport?
It moves solutes against their concentration gradient using energy from ATP hydrolysis.
35
What happens during primary active transport?
Energy from ATP hydrolysis causes a change in the shape of the transport protein.
36
What are examples of pumps involved in primary active transport?
* Calcium pump * Hydrogen (proton) pump * Na+−K+ pump
37
What is the Na+−K+ pump and its primary function?
An enzyme that pumps Na+ out of the cell and K+ back into the cell.
38
Where is the Na+−K+ pump especially active?
In excitable cells such as nerves and muscles.
39
What do leakage channels in membranes result in?
Leaking of Na+ into the cell and K+ out of the cell.
40
What is the role of the Na+−K+ pump in maintaining electrochemical gradients?
It maintains both concentration and electrical charge of ions, essential for muscle and nerve functions.
41
What is the resting membrane potential (RMP)?
Electrical potential energy produced by the separation of oppositely charged particles across the plasma membrane.
42
What is the typical range of membrane voltages in cells?
−50 to −100 milliVolts.
43
What is the primary ion that affects resting membrane potential (RMP)?
K+.
44
How does K+ influence RMP?
K+ diffuses out of the cell, making the inside more negative, and is pulled back by the negative interior.
45
What balances the drive for K+ to leave the cell?
The drive to stay due to the electrical gradient.
46
What role does Na+ play in RMP?
Na+ can also affect RMP but to a lesser extent than K+.
47
What maintains RMP in cells?
The action of the Na+−K+ pump, ejecting 3 Na+ out and bringing 2 K+ back in.
48
What are the three types of endocytosis?
* Phagocytosis * Pinocytosis * Receptor-mediated endocytosis
49
What is exocytosis?
Transport of substances out of the cell.
50
What does vesicular transport involve?
Transport of large particles, macromolecules, and fluids across the membrane in vesicles.
51
What role do cell adhesion molecules (CAMs) play?
* Anchor cells to the extracellular matrix or each other * Assist in movement of cells * Attract white blood cells * Stimulate synthesis or degradation of junctions * Transmit signals for migration and specialization
52
How do membrane receptor proteins function?
They serve as binding sites for chemical signals.
53
What is contact signaling?
Cells recognize each other through unique surface membrane receptors.
54
What is chemical signaling?
Interaction between receptors and ligands that causes changes in cellular activities.
55
What are examples of ligands?
* Neurotransmitters * Hormones * Paracrines