Chapter 33-Fuel metabolism and Obesity Flashcards Preview

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Flashcards in Chapter 33-Fuel metabolism and Obesity Deck (21):

What is defined as obesity?

BMI of 35 or more


What are the trends of obesity in the US and worldwide?

US-1/3 adults and 17% of children are obese
worldwide-1.6billion (25%) of the world is overweight


What are the health consequences of obesity?

1. skeletal muscle insulin resistance and development of type 2 diabetes
2. Diabetes linked end-stage renal disease
3. cardiovascular disease
4. Neurological and psychological issues such as Alzheimer's disease
5. pulmonary disease ie sleep apnea
6. Reproductive issue ie infertility and gestational disease
7. GI such as colon cancer and gallstones
8. Increases skin infections
9. Orthopaedics ie osterarthritis


What are the treatments for obesity?

Lifestyle with low calorie diet and increased physical activity
Pharmacological options that alter nutrient absorption, increase satiety and appetite suppression
surgical treatments ie restrive gastric band and biliopancreatic diversion/duodenal switch


What is energy balance

balance of energy intake and energy expenditure (basic metabolism and physical activity)


What happens when the energy intake is equal to expenditure?

weight maintenance


What happens when energy intake is greater than expenditure?

weight gain (positive energy balance


What happens when energy intake is less than expenditure?

weight loss


What happens when there is perturbation of body weight

it is met with physiological response to counter the changes


What hormones control long term control of intake

insulin and leptin (adiposity signals)


What hormones control short term control of intake

peptide tyrosine tyrosine (PYY) and glucagon-like peptide 1 (GLP-1) induce satiety
Ghrelin induce appetitie


What are some contributors of obesity?

leptin (leptin production is proportional to amount of adipose tissue; deficiency of leptin[ar] causes hunger and severe obesity
diet and physical activity (major contributor)


what hormones induce hunger



What hormones induce satiety?

peptide tyrosine tyrosine (PYY) and glucagon-like peptide 1 (GLP-1)


What is the substrate oxidation and fuel preference in fed and fasted state?

skeletal muscles primarily oxidize fatty acids in the fasted state and switch to carbs in the fed state


How is substrate oxidation assessed?

indirect calorimety


What type of substrate metabolism issues have been observed in obese individuals?

low oxidation metabolism and defects in switching to carbohydrate oxidation (hyperglycemia) in response to insulin


low fat oxidation and excess FFAs signifies what? and what does it indicate?

low insulin sensitivity which is indicative of type 2 diabetes


what happens to skeletal muscles in response to insulin sensitivity?

increased neutral lipid content
decreased glycolytic activity
decreased glut 4 translocation
decreased capillary density
less mitochondrial content concomitant, lower function and impaired oxidative enzyme activity


What does exercise help with?

improving mitochondrial content, substrate oxidation, and insulin sensitivity.


What factors contribute to maintaining energy homeostasis?

extrinsic (environmental) and intrinsic (physiological, genetic) changes occur to maintain energy homeostasis