Chapter 4 Flashcards

1
Q

absorbed

A

When drugs have entered the bloodstream

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2
Q

antagonism

A

the diminished or reduced effect of a drug when another drug is present

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3
Q

as a function of

A

a term expressing correlation. in graphs of functional relationships between two variables, changes in one variable associated with changes in another (drug dose) are represented.

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4
Q

bioavailability

A

The portion of the original drug dose that reaches its site of action or that reaches a fluid in the body that gives it access to its site of action

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5
Q

control

A

In research, to be able to account for variables that may affect the results of a study.

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6
Q

Diffusibility

A

A more diffusible substance is more easily entered into or “receptive” of another

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7
Q

Dissolved

A

When a drug changes from solid to liquid by mixing it with a liquid.

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8
Q

Distribution

A

The transport of drugs by the blood to their site(s) of action in the body.

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9
Q

Drug potency

A

The minimum effective dose of a drug.

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10
Q

Effective dose

A

The dose at which a given percentage of individuals show a particular effect of a drug

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11
Q

Efficacy

A

The most intense, or peak, level of a drug effect

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12
Q

Feedback

A

In this context, in a series of events, what happens in a later event alters events that preceded it.

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13
Q

Freebase

A

When a substance is separated, or “freed” from its salt base. The separated form of the substance is thus called “freebase”.

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14
Q

Half-life

A

The amount of time that must pass for the amount of drug in the body to be reduced by half

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15
Q

Interact

A

When the effects of one drug are modified by the presence of another drug.

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16
Q

Lethal dose

A

The dose of a drug at which a given percentage of individuals die within a specified time.

17
Q

Metabolism

A

The process by which the body breaks down matter into more simple components and waste.

18
Q

Pharmacodynamics

A

The branch of pharmacology that concerns the biochemical and physiological effects of drugs and their mechanisms of action.

19
Q

Pharmacokinetics

A

Refers to the study of “what the body does to the drug” and includes the main processes of absorption, distribution, metabolism, and excretion (known as the acronym ADME)

20
Q

Qualitative

A

The kind, as opposed to quantity, of effect.

21
Q

Side effects

A

Effects of a drug other than those central interest; used most often in reference to the other-than-therapeutic effects of medications, such as the side effect of drowsiness for antihistamines. Note that what are considered a drug’s side effects depend on what specifically the drug is being used for.

22
Q

Slope

A

The steepness or rise of a curve

23
Q

Solubility

A

The ease with which a compound can be dissolved or entered into a solution.

24
Q

Suspended

A

When a drug’s particles are dispersed in solution but not dissolved in it.

25
Q

Synergism

A

Any enhancing drug interaction

26
Q

Therapeutic index

A

A measure of a drug’s safety in medical care; it is computed as a ratio: LD 50/ED50