Chapter 4: Immune Recognition

Question 1

Foreign Pattern Recognition

Answer 1

Recognition of structures that are shared by microbial pathogens and not present on mammalian cells
E.g. LPS, Viral DNA/RNA, PAMP’s recognised by PRR’s

Question 2

Danger (immune recognition)

Answer 2

Recognition of structures found in/on stressed or dying cells
E.g. DAMP’s (heat shock proteins)

Question 3

Missing/Altered Self (immune recognition)

Answer 3

Changes in self proteins such as Dow regulation of MHC I

Question 4

Antigen

Answer 4

Any substance that may be specifically bound by and Immunoglobulin or T cell receptor
A target of the immune response

Question 5

Immunogen

Answer 5

Substance which induces specific immune response e.g. Hapten Carrier

Question 6

Determinant/Epitope

Answer 6

Antibody contact site on antigen

Question 7

Dinitrophenyl (DNP)

Answer 7

Small chemical group which binds but does not trigger immune response

Question 8

Hapten

Answer 8

Small organic moiety attachable to larger structure
Target of antibody response
Non immunogenic

Question 9

Carrier (hapten carrier complex)

Answer 9

Usually protein or polypeptide required for immune response

Must be covalently linked to hapten to create antibody to hapten