Chapter 8: Antigen Presentation

Question 1

TAP

Answer 1

Transported associated with peptide
Involved in MHC I and II processing
Translocates peptides into the ER

Question 2

Cathepsins

Answer 2

Endosomal proteases present in MHC II Processing

Question 3

Invariant chain

Answer 3

Prevents ER polypeptides associating with MHC II

Also acts as a chaperone for MHC II leaving the ER to plasma membrane via the endocytic route

Question 4

Lip10

Answer 4

Results from a protease cleaving the zipper of the invariant chain

Question 5

CLIP

Answer 5

Results when cathepsin cleaved Li-p10

Keeps MHC II in closed conformation

Question 6

HLA-DM

Answer 6

Chaperone which induces an open conformation of the MHC II by interacting with CLIP