Chapter 4/Movement of Molecules Across Cell Membranes Flashcards
Movement of molecules from one location to
another as a result of their random thermal
motion
Diffusion
Magnitude of net flux influenced by:
-Temperature
– Mass of the solute
– Surface area
– Medium
Diffusion time _ in proportion to the _ of the distance over which the
molecules diffuse
increases , square
Limited _
* Diffusion is _over a long distance
not effective, distance
Membranes considerably slow the diffusion of
molecules
across their surfaces
O2, CO2, fatty acids, steroid hormones
rapidly through membranes.
diffuse
Polar molecules __readily through
membranes.
do not, diffuse
Ions (Na+, K+, Cl–, Ca2+) use __ to diffuse in and out of the ;\;’
protein channels, cell
channels form
integral membrane protein
Specificity of channel is determined by .
pore
size, charge, and binding sites
Separation of electrical charges across the
plasma membrane
Membrane potential
Diffusion of ions influenced by
concentration
and membrane potential
Channels are regulating
to control movement
of ions in and out of the cell
Type of gated channels
-Ligand-gated
– Voltage-gated
– Mechanically gated
Molecules that are too large and charged
Mediated Transport Systems
Protein transporters bring these molecules
into and out of the cell
Magnitude of net flux influenced by
-Solute concentration
– Affinity of transporters for solute
– Number of transporters
– Rate of conformational change
Facilitated diffusion
-Net flux from high to low concentration
– Uses transporter to move solute across membrane
-Uses energy
– Moves solute against the concentration gradient
Active transport
ATPase: hydrolysis of ATP
Use ATP directly
-Found in every cell
– Helps establish and maintain membrane potential
Na+/K+-ATPase
Use electrochemical gradient across
membrane as energy source
Secondary Active Transport
- Ion
– Cotransported molecule
Two binding sites
move
molecules in same
direction
Cotransporters