Chapter 40- Papilloma and Parvovirus Flashcards Preview

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Flashcards in Chapter 40- Papilloma and Parvovirus Deck (12):

Describe parvovirus B19

small, naked, single stranded DNA


Fifth Disease

Caused by parvovirus B19. grows in red blood cells and can lead to aplastic crisis. Causes slapped rash, which is a rash that develops when no longer contagious. the diagnosis for fifth disease is done from the rash.


Polyomaviridae characteristics

double stranded DNA, naked capsule with icosahedral symmetry. Uncommon oncogenic potential. Genome integrated in transformed cells.


Papillomaviridae characteristics

double stranded DNA, naked capsule with icosahedral symmetry. common oncogenic potential. Genome circular in warts, integrated in carcinoma.


describe the human papillomavirus characteristics

nonenveloped double stranded circular DNA


Progression of HPV infection

virus is highly tropic for epithelial cells of skin and mucus membrane. development of epithelium is essential for development of virus particles.


Genital infections

most HPV serotypes are not associated with condyloma acuminatum (CA) but several are (ex 16 & 18). most genital hpv infections are transient, asymptomatic and have no clinical consequences in immunocompetent individuals.


Median duration of new cervical infections

8 months


Persistent HPV infection

- not cleared by immune system
- characterized by persistently detectable type-specific HPV DNA.
- persistent oncogenic HPV infections is most important risk factor for pre cancerous cervical cellular changes and cervical cancer.


what can happen to babies born to mothers that have genital warts

they can occasionally develop warts in the respiratory tract.


GARDASIL vaccine

polyvalent vaccine. Capsid protein antigen made in yeast; the capsid proteins then self assemble to "look" like the virus but can't replicate. Four types: 6, 11, 16, 18


Cervarix vaccine

for females only, covers types 16 and 18