Chapter 43- Hepatitis Flashcards Preview

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Flashcards in Chapter 43- Hepatitis Deck (17):
1

Describe Hepatitis A

picornaviridae. non enveloped ss (+) RNA

2

Hepatitis A incubation time

about 1 month

3

Hepatitis A pathogenesis

Virus produced in hepatocytes and Kupffer's cells. Virus released into bile and shed through stool. Large quantities shed about 10 days before jaundice. Does not cause chronic liver disease, and rarely fatal.

4

Diagnosis of Hepatitis A

serological tests -> anti-HAV IgM

5

Treatment and prevention of Hep A

Interrupt the fecal-oral spread. immune serum globulin (pooled): during incubation. Inactivated (killed) HAV vaccine

6

Describe Hepatitis E

Icosohedral, non enveloped, + sense ss RNA. Hepeviridae.

7

Describe Hepatitis B

Hepadnaviridae. small, enveloped, partially ds DNA

8

HB_Ag's of Hepatitis B

HBsAg- envelope protein
HBcAg- core Ag
HBeAg- minor Ag

9

Hepatitis B incubation time

2-3 months

10

High, moderate and low levels for transmission

High- blood, serum
Mod- semen, vaginal secretions, saliva
low- urine, feces, tears, sweat

11

Complications from Hep B

primary hepatocellular carcinoma. cirrhosis. carrier, often for life.

12

Diagnosis of Hep B

Clinical symptoms, liver enzymes, detection of HBsAg, alphaHBsAb, and alphaHBcAb

13

Hepatitis B vaccine's

1) 3 dose series
2) 2 dose adult series

14

Babies born to mom with hep b infection.

Give immunoglobulin

15

Describe Hepatitis D

Deltavirus. defective ss (-) RNA. Envelope protein composed of HBsAg. requires helper function of HBV to replicate.

16

Describe Hepatitis C

Flavivirus. + sense ss RNA enveloped. Spread by blood.

17

Diagnosis of Hep C

symptoms and liver enzymes. ELISA recognition of Ab- seroconversion occurs within 7-31 weeks of infection. positive tests are confirmed by viral RNA tests which determines the amount of virus in the body.