Flashcards in Chapter 41 - Rheumatologic Disease Deck (14):
Which hepatic disease has been associated with anticentromere antibodies?
Primary biliary cirrhosis
Which auto-antibody is most associated with neonatal lupus?
Anti-Ro, but also anti-La
Which three antibodies are most closely associated with Sjogren's syndrome?
Alpha-fodrin, Ro, and La
*Alpha-fodrin auto-antibodies are more common that Ro and La auto-antibodies
Which two auto-antibodies are most closely associated with rheumatoid arthritis?
Rheumatoid factor and anti-cyclic citrullinated protein (CCP) antibodies
*Anti-CCP targets citrullinated proteins in the skin (e.g. fillagrin) and joints
What is the molecular target of rheumatoid factor?
Fc portion of IgG
What symptom or sign of SLE is dsDNA autoantibody associated with (i.e. which type of organ dysfunction)?
*dsDNA can also be used to monitor SLE disease activity
Which 3 autoAb have the highest specificity for SLE?
Anti-dsDNA, Sm, rRNP
What serologic marker is common amongst all AI CTDs (ie. SLE, RA, SSc, dermatomyopathy)?
U1RNP, which also defines the concept of mixed CTDs
What are some drugs that can cause drug induced ANA/SLE?
Procainamide, hydralazine, isoniazid, chlorpromazine, phenytoin, methyldopa, minocycline, TNF-alpha inhibitors
What are the signs and symptoms of drug induced ANA/SLE?
MSK (arthritis, arthralgia, myalgia), serositis (pleuritis, pericarditis), positive ANA, positive anti-dsDNA, skin findings (malar rash, SCLE, DLE, photosensitivity and purpura), phlebitis (with anticardiolipin antibodies), leukopenia, thrombocytopenia, general manifestations (fever, weight loss, asthenia)
Does age have an effect on ANA levels?
Yes, up to 15% of otherwise healthy individuals of >55yo can be found to have a significantly elevated ANA titer of no apparent clinical consequence
What type of bloodwork would you order for a patient who you SUSPECT has an AI CTD?
ANA. Then anti-dsDNA, anti-Sm, CBCd, Cr, albumin, total protein, ESR, U/A, C3, C4
What pattern of nucelar immunofluorescence may be clinically significant?
Centromeric/discrete speckled pattern, which is specific for Ab to chromosomal centromers (CENP-B) seen in CREST sydrome