Chapter 6

Question 1

Why can’t non-living vaccines induce cytotoxic T cells?

Answer 1

Because they cannot enter MHC 1 pathway.

Question 2

Which pathways can live vaccines enter and what limits their use?

Answer 2

MHC 1 and 2, inducing cytotoxic T cells and T helper cells. They cannot be given to pregnant women, immunocompromised patients and they require refrigeration.

Question 3

Give examples on killed intact bacterial vaccines.

Answer 3

Pertussis, cholera, and TAB.

Question 4

Give an example on live attenuated intact bacterial vaccines.

Answer 4

BCG against TB

Question 5

What are examples on toxoid vaccines?

Answer 5

Tetanus and diphtheria.

Question 6

What are examples on intact viral live attenuated vaccines?

Answer 6

MMR and Sabin OPV

Question 7

When is MMR vaccine administered in children?

Answer 7

At 12 and 18 months.

Question 8

When is DPT vaccine administered in children?

Answer 8

At 2,4,6 months then at 18months.

Question 9

What vaccine is recommended for pregnant health care workers?

Answer 9

TdaP.