Chapter 6 Innate Immunity, inflammation, wound healing Flashcards
Eosinophils
defends against parasites and regulates vascular mediators ; see an increase when fighting allergies
monocytes and macrophages
monocytes- are produced in bone marrow
macrophages - arrive 24 hrs or later after neutrophils
leukocytes
White blood cells
dendritic cells
location: skin and organs
interact with T lymphocytes to generate an acquired immune response
neutrophiles
ends up as pus; responds around 6-12hrs; cells are short lived
basophils
unknown role; have the lowest amount that we have in our body
phagocytosis
process by which cells ingest foreign material
Natural killer Cells
- recognize and eliminate cells infected with viruses
- produce cytokines and toxic molecules
lymphocytes
B & T cells
Wound healing (4 stages)
Regeneration: Being reformed
- resolution: returning injured tissue to the original structure and function
- Repair replacement of destroyed tissue with scar tissue
- Healing: filling the wound, (epithelialization) sealing the wound, (contraction ) shrinking the wound
Wound healing (2)
primary intention: heal under conditions of minimal tissue loss. the edges are brought together well with surgical sutures
Ex: paper cut
secondary intention: wound that require a great deal of more tissue replacement. higher risk for infection, heals from inside out
Ex: pressure injury
wound healing (3 phases)
-Inflammation phase: coagulation, angiogenesis
-Proliferative phase: granulation, makes more of , susceptible to infection
-Remodeling and maturation phase: scar tissue formation, rebuilding collagen
Dysfunctional wound healing
can occur: ischemia , excessive bleeding, excessive fibrin deposition
dehiscence
closed wound, separating & opening
evisceration
cause bowels or organs to be exposed
