Chapter 6 Questions Flashcards

(14 cards)

1
Q

When do chromosome rearrangements occurs?

A

When double strand breaks occur in DNA molecules found within a chromosome.

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2
Q

When do problems in chromosome pairing occur in heterozygotes?

A

During prophase I in meiosis.

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3
Q

How do duplications and deletions often arise?

A

From unequal crossing over, in which duplicated segments of chromosomes misalign during the process.

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4
Q

What is gene dosage?

A

The amount of a particular protein synthesized by a cell is often directly related to the number of copies of its corresponding gene: an individual organism with 3 functional copies of a gene often produces 1.5 times as much protein encoded by that gene as an individual with 2 copies.

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5
Q

Why do chromosome duplications often result in abnormal phenotypes?

A

Because developmental processes depend on the relative amounts of proteins encoded by different genes.

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6
Q

How is pseudodominance produced by a chromosome deletion?

A

When a wild-type allele on a homologous chromosome gets deleted.

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7
Q

What can an inversion do?

A

Break a gene into two parts and one part may move to a new location and destroy the function of the gene in that location.

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8
Q

What is the difference between an individual who is homozygous for an inversion and one who is heterozygous?

A

Someone who is homozygous will have no special problems arising in meiosis and the 2 homologous chromosomes can separate normally. In heterozygous inversion, the sequences of the homologous chromosomes can only align if the two chromosomes form an inversion loop, they also exhibit reduced recombination.

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9
Q

When is a dicentric chromosome produced?

A

During crossing over in a heterozygous paracentric inversion.

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10
Q

How can translocations effect the phenotype?

A

They can physically link genes that were formally on different chromosomes, they can break a gene and disrupt its function.

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11
Q

What is the outcome of a robertsonian translocation?

A

One large chromosome and one very small chromosome with two very short arms.

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12
Q

Why are sex chromosome anueploidies more common than autosomal anueploidies?

A

Dosage compensation prevents additional copies of X linked genes in mammals, and there is little information on the Y chromosome so extra copies of X and Y have little effect on development.

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13
Q

Why does autopolyploidy usually result in sterility?

A

Because all chromosome sets are from the same species, they are homologous and when they attempt to line up in prophase I of meiosis it results in sterility. On

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14
Q

What is the significance of polyploidy?

A

An increase in chromosome number is often associated with an increase in cell size.

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