Chapter 6 - WBC and PLATELET STUDIES

Question 1

• Large purple to black azurophilic granules

Answer 1

Toxic granulation

Question 2

altered primary granules

Answer 2

Toxic granulation

Question 3

Severe infection

Answer 3

Toxic granulation

Question 4

chemical poisoning

Answer 4

Toxic granulation

Question 5

toxic states

Answer 5

Toxic granulation

Question 6

• larger than 2° granules and stain dark blue - black.

Answer 6

Toxic granulation

Question 7

blue, round or elongated bodies

Answer 7

Doble bodies /Amato

Question 8

Single or multiple, arranged in parallel rows

Answer 8

Doble bodies /Amato

Question 9

Aggregates of free ribosomes

Answer 9

Doble bodies /Amato

Question 10

Severe infections, burn, surgery

Answer 10

Doble bodies /Amato

Question 11

chemotherapy

Answer 11

Doble bodies /Amato

Question 12

May - Hegglin

Answer 12

Doble bodies /Amato

Question 13

Large empty areas within the cell

Answer 13

Cytoplasmic vacuolation

Question 14

Represents end stage of phagocytosis

Answer 14

Cytoplasmic vacuolation

Question 15

Septicemia, severe infections, toxic states

Answer 15

Cytoplasmic vacuolation

Question 16

Cells show foamy cytoplasm

Answer 16

Atypical/Reactive lymphocyte/ Downey cells

Question 17

seen in Infectious Mononucleosis

Answer 17

Atypical/Reactive lymphocyte/ Downey cells

Question 18

Neutrophils have single or bilobed nuclei

Answer 18

Hypolobulation

Question 19

Decreased segmentation

Answer 19

Hypolobulation

Question 20

Pelger-Huet Anomaly

Answer 20

Hypolobulation

Question 21

Neutrophils show more than 4 lobes

Answer 21

Hypersegmentation

Question 22

Abnormal DNA synthesis

Answer 22

Hypersegmentation

Question 23

Megaloblastic anemia

Answer 23

Hypersegmentation

Question 24

shrunken and dehydrated nucleus of cells that are about to die

Answer 24

Pyknotic cell

Question 25

nuclear remnant of lymphocyte, seen after smear preparation

Answer 25

Smudge cell

Question 26

Thumbprint appearance; associated with CLL

Answer 26

Smudge cell

Question 27

nuclear remnants of granulocytic cell

Answer 27

Basket cell

Question 28

drumstick like body attached on one of the lobes of neutrophil nucleus

Answer 28

Barr Body

Question 29

Pink or red rod-shaped structures

Answer 29

Auer rods

Question 30

Fused primary granules; Seen in AML

Answer 30

Auer rods

Question 31

Large, coarse blue-black granules in all WBCs

Answer 31

Alder - Reilly Granulation

Question 32

abnormal polys accharide metabolism which prevents the formation of secondary granules

Answer 32

Alder - Reilly Granulation

Question 33

characterized by leucopenia, variable thrombocytopenia, giant platelets

Answer 33

May - Hegglin anomaly

Question 34

Presence of gray - blue spindle shaped inclusions in the cytoplasm of Neutrophils and Monocytes

Answer 34

May - Hegglin anomaly

Question 35

Random movement of phagocytes is normal but directional motility is impaired

Answer 35

Job's Syndrome

Question 36

Cells respond slowly to chemotactic agents

Answer 36

Job's Syndrome

Question 37

Characterized by large, blue to grayish granules in Neutrophils that vary in size and color and stain positive with peroxidase, Sudan black B (SBB) and Acid phosphatase (ACP) stains.

Answer 37

Chediak Higashi Anomaly

Question 38

granules are normal in content but abnormally packaged

Answer 38

Chediak Higashi Anomaly

Question 39

Phagocytes ingest but cannot kill catalase (+) organism because of lack of appropriate respiratory burst

Answer 39

Chronic Granulomatous Disease

Question 40

screening test for neutrophil function (ability of neutrophils to attack bacteria)

Answer 40

NTR (Nitroblue Tetrazolium Reduction ) test

Question 41

yellow water soluble dye is reduced to insoluble blue formazan

Answer 41

NTR (Nitroblue Tetrazolium Reduction ) test

Question 42

tests migration of N in response to a chemotactic factor

Answer 42

Boyden micropore filter

Question 43

evaluates the speed, type and number of phagocytes that respond to a skin abrasion

Answer 43

Rebuck skin window

Question 44

emission of low-level light pulses by stimulated cell

Answer 44

Chemiluminescence:

Question 45

a stimulated or atypical lymphocyte with denser and more opaque cytoplasm

Answer 45

Ferrata cell

Question 46

associated with SBE

Answer 46

Ferrata cell

Question 47

a lymphocyte with notched, lobulated, segmented, clover leaf like nucleus

Answer 47

Reider Cell

Question 48

associated with chronic lymphocytic leukemia

Answer 48

Reider Cell

Question 49

Neutrophil with large purple homogenous round inclusion with nucleus wrapped around

Answer 49

L.E. cell

Question 50

A lymphocyte with hair-like cytoplasmic projections

Answer 50

Hairy cell

Question 51

Round lymph cell with nucleus that is grooved or convoluted

Answer 51

Sezary cell

Question 52

Seen in Sezray syndrome

Answer 52

Sezary cell

Question 53

plasma cell with red to pink cytoplasm; Associated with increase in IgA

Answer 53

Flame cell

Question 54

plasma cell that contains small colorless (or blue or pink) vacuoles

Answer 54

Grape cell/Mott cell, Morula cell

Question 55

large protein globules giving the appearance of grapes

Answer 55

Grape cell/Mott cell, Morula cell

Question 56

Mucopolysaccharidoses

Answer 56

I Hurlers II Hunters III Sanfilippo IV Morquio Ullrich V Scheie VI Maroteaux Lamy

Question 57

lack of b- glucosidase resulting to the accumulation of glucocerebrosides in the spleen, liver and bone marrow

Answer 57

Gaucher’s disease

Question 58

Gaucher cell cytoplasm is distended with glucocerebroside; spongelike appearance

Answer 58

Gaucher’s disease

Question 59

deficiency of sphingomyelinase resulting to accumulation of sphingomyelin and cholesterol in the macrophages

Answer 59

Niemann Pick disease

Question 60

accumulation in the spleen and BM of histrocytes filled with lipid- rich granules that stain blue green with polychrome stains

Answer 60

Sea blue histrocytes

Question 61

s/s: hepatomegaly, thrombocytopenia

Answer 61

Sea blue histrocytes

Question 62

lack of a-galactosidase resulting to accumulated glycolipid trihexosyl ceramide

Answer 62

Fab deae

Question 63

deficiency of acid esterase resulting to accumulation of TG and cholesterol

Answer 63

Wolman Disease

Question 64

Patient is unable to produce HDL, as a result, cholesterol esters accumulate

Answer 64

Tangier’s disease