Chapter 65 and 72

Question 1

Santamaria JAVMA 19
SQ infusion of carboplatin

Answer 1

Protocol not recommended

Question 2

Marconato JAVMA 21
Timing of adjuvant chemo

Answer 2

tumor progression was longer in dogs that received chem <5 days than those who were >5days post op

timing of chemo is an important prognostic variable

Question 3

Magidenko JAVMA22
Double limb amps

Answer 3

Most common indication: trauma
owners happy 17/18 cases
comps 3/18 with 2 needing revision
may be viable alternative

Question 4

Hans VS 18
Effect of SSI on limb amp

Answer 4

Median DFI and MST did NOT differ between those with SSI and those without
Failure to complete chemo was associated with decreased DFI and survival

Question 5

Billas VS 22
Risk factors for SSI after ampt

Answer 5

12.5% SSI
Factors that increased odds: bipolar sealing device, non-clean procedure, amp for infection or trauma

Question 6

Gilliano VS 22
SQ VAP implantation

Answer 6

Jugulars had the most complications
Axillary and femoral were alternatives

Question 7

Caraway JSAP 18
Tail avulsion in cats

Answer 7

All lost voluntary fxn, 8/15 urinary incant
Post op: 11 cats recovered motor/sn in 40 days and 5/9 recovered incontinence in 1 month

Question 8

Giuffrida VS 18
HSA vs OSA

Answer 8

● 41 HAS, 29 tOSA
● Dogs with HSA were more likely to be: Male, have hindlimb tumors (78%, esp the tibia)
● Dogs with tOSA weighed 9.9kg more than HSA cases
● Most dogs had amp +/- chemo
o MST: 299d (10m) HSA
o MST 210d (7m) tOSA
● Both tumors were aggressive with a high rate of pulmonary mets

Question 9

Selmic JAVMA 18
TPLO and OSA

Answer 9

● Dogs with a history of TPLO ≥ 1y prior were 40x more likely to develop proximal tibial OSA than dogs without TPLO
● Each 1 kg BW increase = 11% increase in odds of proximal tibial OSA

Question 10

Nakano JAVMA 22
Cats OSA

Answer 10

● 46% overall distant metastatic rate
● osteosarcoma of the humerus was significantly associated with distant metastasis
● 10% local recurrence
● median survival time 527 days

Question 11

Jones JAVMA 20
Rad features of benign vs malignant

Answer 11

● only 50% of benign infarcts and 40% of malignancy-associated infarcts were correctly classified
● 70% of benign lesions had medullary lysis (100% of malignant lesions did)
● radiology was not particularly helpful in distinguishing benign from malignancy-associated bone infarcts in dogs

Question 12

Matsuyama JAVMA 18
cyclophosphamide chemo

Answer 12

● 19 dogs received carboplatin and MC chemotherapy, and 20 dogs received only carboplatin chemotherapy
● Median duration of MC chemotherapy for dogs in the carboplatin-MC group was 94 days (range, 7 to 586 days)
● treatment was discontinued for 11 (58%) dogs when cystitis developed. (consider prophylactic tx with furosemide)