Chapter 8 Notes

Question 1

red neck syndrome and Vanco

Answer 1

anaphylactoid reaction of histamine release due to mast cells.
prevent by slow infusion rate, inc solvent vol, treat with 1st gen antihistamines prophylatically

Question 2

ototoxicity and vanco

Answer 2

rare in most cases unless there is accumulation of vanco or there is concurrent use of other ototoxic drugs

Question 3

nephrotoxicity and vanco

Answer 3

incidence is low when vanco is used alone. Increase incidence when used with Aminoglycoside

Question 4

hyperbilirubinemia and vanco

Answer 4

common ADR but not consequential

Question 5

vanco DDI

Answer 5

bile sequestrants

Question 6

fosfomycin and cycloserine

Answer 6

work in the cytoplasm

Question 7

bacitracin

Answer 7

polypeptide that inhibits membrane transporter activation.
Use: G +
Too toxic for IV
not absorbed or bioavailable

Question 8

peptide structure in vanco does

Answer 8

all H bonding

Question 9

ligase is VanA

Answer 9

gene product occurs in enterococci

Question 10

VAREF

Answer 10

enterococci that are resistant to vanco, ampicillin

Use linzeolid and quinupristin/dalfopristin = AOC

Question 11

Vanco binds well to

Answer 11

D-Ala - D-Ala

but not D-Ala - D-lac or D-Ala

Question 12

Vanco is the AOC in

Answer 12

MRSA, MRSE, serious PRSP, and enterococci

Question 13

Vanco can be used in 2 specific infections

Answer 13

CDAD (only in pt who fail metronidazole) or staph enterocolitis

Question 14

Change dosing interval when you have renal pt taking

Answer 14

vanco

Question 15

Daptomycin MOA

Answer 15

partitions into bacterial inner membrane and aggregates. It binds Ca2+ and then transports Ca2+ into the cell. This causes K+ to be pumped out of the cell. You now have disrupted ion balance.

Question 16

daptomycin can be used in these disease states

Answer 16

wounds, abscesses, bone and joint, bacteremia, endocarditis, and complicated skin infections

Question 17

red man syndrome

Answer 17

FQ, telavancin, vanco