Chapter 9 skeletal muscle Flashcards

(50 cards)

1
Q

Describe skeletal muscle and its function

A

striated and voluntary
multi-nucleate
produces movement of the skeleton

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2
Q

describe smooth muscles and its function

A

unstriated and involuntary
one nucleus per long cell
constricts blood vessels and allows for organ mobility

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3
Q

describe cardiac muscle and its function

A

striated and involuntary; features branching and intercalated discs
serves as the pump for the circulatory system

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4
Q

list four functions of muscle tissue

A

excitability - ability to respond electrically to a stimulus
Contractibility – ability to shorten forcibly
Extensibility – ability to extend or stretch
Elasticity – ability to recoil after being stretched

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5
Q

skeletal muscles are also referred to as _____?

A

muscle fibers

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6
Q

describe what a prime mover is

A

a primary muscle group that does most of the work - agonist

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7
Q

describe what as synergist is

A

muscles that assist the prime mover

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8
Q

describe what an antagonist is

A

muscles that resist or work against the prime mover

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9
Q

describe how first class levers work

A

consists of fulcrum being at center

ex. elbow acts as fulcrum when lifting a weight. the weight is the resistance to the triceps acting as the force

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10
Q

describe how second class levers work

A

resistance is in the middle

ex. fulcrum at toes, resistence (body weight), force of calf muscles when jumping

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11
Q

describe how third class levers work

A

force is in the middle

ex: doing bicep curls. ulna acts as bar, elbow is fulcrum, force of bicep is pulling on ulna (so centered) weight is on end

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12
Q

what is constant and what is changing in isotonic contraction and does it produce movement?

A

Constant: tension
Changing: length
produces movement

think of picking up a weight

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13
Q

what is constant and what is changing in isometric contraction and does it produce movement?

A

constant: length
changing: tension
produces no movement

think of picking up an immovable weight such as heavy table

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14
Q

what is the difference between concentric and eccentric give an example of each?

A

concentric: muscles shorten
(picking up a weight, biceps contract)
eccentric: muscles lengthen
(dropping a weight down, bicep relaxes and stretches)

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15
Q

describe the differences between endomysium, perimysium, and epimysium

A

Endomysium – around individual cells
Perimysium – around fascicles (clusters of muscle cells)
Epimysium – around entire muscle

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16
Q

what is muscle fascia and what does it connect with?

A

connects with epimysium of muscles to help connect muscles together

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17
Q

what are two derivatives of fascia and give examples

A

tendons - cord-like connective tissue (such as within the shoulder and knee)
aponeuroses - sheet-like connective tissue (such as between abdominal muscles)

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18
Q

describe myofibrils, where they can be found and their function

A

myofibrils make up muscle fibers or myocytes

their primary function is to house the actin and myosin to facilitate movement within the muscle cell

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19
Q

define sarcomeres and where you find them

A

sarcomeres refer to the region of a myofibril between two z-discs

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20
Q

sarcoplasmic reticulum, what is it most similar to among other cells, where you will find them, and what is their function?

A

most similar to smooth endoplasmic reticulum of cells
they surround myofibrils like a loose knit sweater
their function is to release calcium to the thin filament

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21
Q

define sarcolemma, its location and function

A

most similar to cell plasma membrane

works to divide intracellular material and organelles from extracellular material

22
Q

define T-tubules, where they are located, and what is their function

A

t-tubules are channels that lead within the myocyte in order to quickly transfer electrical signal to the sarcoplasmic reticulum in order for it to release calcium to the thin filament

23
Q

where is the I-band located

A

where only z-disc line and thin filament are present

24
Q

what is the z-line’s function

A

anchor site for actin (thin) filament and titin

25
where does the a-band contain?
entire myosin (thick) region, including the portion where thick and thin filaments overlap
26
where is the h-zone?
center portion of myosin (thick) where actin (thin) does not overlap
27
where is the m-line located and its function
centermost part of myosin (thick) and it is the attachment site for myosin
28
describe the sliding filament model of muscle contraction
Movement of myosin head is what produces movement of contraction The myosin receives signals through its heads from actin (thin) filament, which causes the myosin heads to pull the thin filament towards its centermost part. This causes a shortening of the tissue size.
29
Describe how the I-band, A-band, H-zone, M-line, Z-line (or Z-disc) of the sarcomere change after contraction.
I-bands shorten Two A bands get closer together but do not change overall size H zones disappear distance between two M-lines gets shorter Distance between two z discs shorten
30
which is the thick filament?
myosin
31
which is the thin filament?
actin
32
what are the different parts of myosin and what do they do?
rod - attaches to M line within the sarcomere | head - produces movement of the myosin
33
what are three properties of the head of myosin?
it is "hinged" which allows for movement binds to actin enzymatic activity
34
explain how muscle fibers are stimulated to contract by describing events that occur at the neuromuscular junction
1. motor neuron fires an action potential down its axon 2. voltage-gated Ca channels open, releasing Ca into synaptic vesicles filled with Acetocholine 3. Influx of Ca triggers vesicles to migrate out into the synaptic cleft through process of exocytosis
35
what allows for ligand-gated Na channels to close after being opened by the Acetocholine?
enzyme Acetocholinesterase
36
Follow the events of excitation-contraction coupling that lead to cross bridge activity
1. ACh binds to ligand-gated Na channels on the sarcolemma which allows for them to open 2. Once opened, Na+ flows into the cell and causes electrical changes or depolarization to occur. 3. This ionic change allows for action potential to flow along the sarcolemma and open voltage-gated Na channels which allows or more sodium to flow into the cell which results in sequential action potential 4. this action potential (charge) opens voltage-gated potassium (K+) channels open and allow for potassium to move out of the cell
37
describe the steps of a cross bridge cycle, including relaxation
1. The action potential that travels along the sarcolemma eventually ends up going down the T tubules and signals the sarcoplasmic reticulum to release its calcium. 2. calcium then binds to the troponin of the actin, which allows the actin to change shape and expose its “active sites” 3. myosin can now bind to these active sites (crossbridge) and allow for contraction of the individual myofibril 4. Phosphate is released from the head of the myosin allowing the myosin to contract, after the power-stroke it also releases ADP 5. ATP is required to release myosin head from actin. (during death, without ATP production, rigormortis occurs) 6. ATPase breaks down ATP from myosin, returning it to Phosphate and ADP. The process of hydrolysis (breaking down) the ATP creates energy and cocks back the myosin head, leaving the myosin ready for another contraction 7. titan is elastic and allows for myosin to spring back to normal state
38
how does myosin heads contract or pull toward its center?
Phosphate is released from myosin head. Head contracts and then releases remaining ADP
39
how does myosin release from actin
ATP attaches itself to myosin head and allows myosin to detach from actin
40
what is the process that breaks down ATP after the detachment of myosin head and actin and why is this process important?
hydrolysis - allows for breaking down of ATP to leave phosphate and ADP the process of enzymatically breaking down ATP creates energy which allows the myosin head to cock back into place, ready to attach itself back to actin
41
define a motor unit
consists of one motor neuron and all the muscle fibers it supplies
42
define muscle twitch
response (rapid contraction) to a single muscle stimulus
43
describe the three periods within a muscle twitch
latent period - first few milliseconds following stimulation when no tension has yet occurred contraction period - cross bridges are actively working (peak tension) relaxation period - Ca+ is pumped back into SR; muscle tension decreases; baseline is returned
44
explain what summation is
multiple motor units being recruited depending on force needed for a task
45
what does force depend on
force depends on the number of myosin cross-bridges formed on actin
46
what does velocity and duration depend on?
fiber type (fast fibers vs slow) load (heavy vs light) recruitment (summation)
47
describe how exercise increases muscle strength
regular resistance cause muscles to hypertrophy (increase size) the bulkier the muscle, the more tension it can develop ability to recruit more motor units through training
48
what occurs during the latent period of a muscle twitch?
stimulus is sent which sends action potential down sarcolemma Ca++ released into cytosol
49
what occurs during the contraction phase of a muscle twitch?
cross bridges are formed | myocyte shortens
50
what occurs during the relaxation phase of a muscle twitch?
Ca++ actively transported back | myocyte lengthens