chemo lecture 2 Flashcards
(33 cards)
primary prevention for
Cervical cancer
Clean sex
primary prevention for
Mouth/Lung/Oral cavity/Esophagus/Pancreas CA
No smoking
primary prevention for
Ca of the breast/Stomach/Oropharynx
HIgh Vit A,C,E
primary prevention for
Liver CA
Hep B vacc/
No moldy food
No pesticide
primary prevention for
Lung CA
No asbestos in workplace
Secondary prevention for
Cervical cancer
Pap smear
Acetic acid wash
Secondary prevention for
COLON CA
FOBT Colonoscopy >50y/o
Secondary prevention for
Oral Cavity CA
Bi annual oral cavity exam
Secondary prevention for
Breast CA
30 y/o Monthly BSE
30 y/o Annual BE
55 y/o Mammogram
Secondary prevention for
Rectum/Prostate CA
DRE
>50 y/o Sigmoidoscopy
Secondary prevention for
Stomach CA
Gastroscopy
Decrease/disappearance of symptoms
Remission
Supportive care
Palliative
1st step treatment before definitive therapy
Neo-adjuvant
Additional cancer therapy after definitive therapy
Adjuvant
Failure of treatment/relapse
Salvage therapy
use of drugs to inhibit or kill proliferating cells/ host cell unharmed or at least recoverable
Chemotherapy
COMBINATION RATIONALE
DRAMTS counter capability Different MOA Rescue normal cells counter side effects Antitumor activity/capability to reduce size Minimal overlapping toxicities Tumor resistance Synergistic effect
classification of tumor cells
Proliferating
Non-proliferating
ratio of proliferating cells in the whole tumor
Growth fraction
faster proliferation=
bigger GF= higher sensitivity of tumor to drug
Early stage
Tumor is bigger-drug effect is better
cells make preparation for DNA synthesis
G1/Gap 1/ Pre-synthetic phase
cells synthesize DNA
S phase
