Chemotherapy

Question 1

What chemo protocol is used mainly for canine lymphoma? What about feline lymphoma?

Answer 1

Canine -discontinuous CHOP/CEOP

Feline - high dose COP

Question 2

Which is more effective for lymphoma - discontinuous CHOP or CEOP?

Answer 2

CEOP

Question 3

What are the drugs in discontinuous CHOP?

Answer 3

C - Cyclophosphamide
H - Epirubicin/doxorubicin
O - Vincristine
P - Prednisolone

Question 4

What are the drugs in discontinuous CEOP?

Answer 4

C - cyclophosphamie
E - etoposide
O - vincristine
P - prednisolone

Question 5

What chemo protocol is used for feline lymphoma?

Answer 5

High dose COP
Cyclophosphamide
Vincristine
Prednisolone

Question 6

Which chemotherapy drugs have cumulative cardiotoxicity?

Answer 6

Doxorubicin
Epirubicin
(H in CHOP)

Question 7

Which chemo drug is hepatotoxic?

Answer 7

Lomustine

Question 8

Which chemo drugs are nephrotoxic?

Answer 8

Cisplatin
Lomustine (dogs)
Doxorubicin (cats)

Question 9

What type of cystitis do chemo drugs cause?

Answer 9

Sterile haemorrhagic cystitis

Question 10

Which drug causes fatal non-cardiogenic pulmonary oedema in cats?

Answer 10

Cisplatin

Question 11

Which chemo drug causes sterile haemorrhagic cystitis? How can this be prevented?

Answer 11

Cyclophosphamide

Give furosemide to encourage urination

Question 12

What is the difference between drug density and intensity?

Answer 12

Density = frequency of administration
Intensity = dose compared to maxium tolerated dose (MTD)

Question 13

Which tumour can be treated/prevented with immunotherapy?

Answer 13

Canine melanoma vaccine

Question 14

What is metronomic chemo?

Answer 14

Continous low dose chemo

cyclophosphamide, NSAID +/- thalidomide

Question 15

What do the following terms mean in terms of chemo?
Primary
Adjuvant
Neoadjuvant
Concurrent

Answer 15

Primary = sole therapy
Adjuvant = after surgery 
Neoadjuvant = before surgery 
Concurrent = given with radiotherapy

Question 16

Give examples of chemo toxicities and when they occur

Answer 16

Anaphylaxis/hypersensitivity - within 24 hours
Anorexia, nausia, D+ 1-5 days
Pyrexic, neutropenic or asymptomatic neutropenic 7-10 days

Question 17

If a patient becomes pyrexic and neutropenic 7-10 days after chemotherapy, what should be done?

Answer 17

Stop all cytotoxic drugs

May be septic - supportive treatment and antibiotics required

Question 18

Which oral drugs are licensed for MCTs in dogs?

Answer 18

Masitinib

Toceranib