Chemotherapy Flashcards
(29 cards)
What is the MOPP regimen composed of?
Mechlorethamine
Oncovin (vincristine)
Procarbazine
Prednisone
What is the ABVD regimen composed of?
Adriamycin
Bleomycin
Vinblastine
Dacarbazine
Why is mopp not used anymore?
Long term complications
When is HSCT done for cancer patients ?
Lack of complete remission
Or relapse before 1 year
When is Brentuximab vedotin used (AAVD)?
With or without HSCT for patients with failed treatment
What is the target of rituximab?
B-cell CD20
What is RCHOP regiment composed from?
Rituximab
Cyclophosphamide
Doxorubicin
Oncovin (vincristine)
Prednisone
How many cycles is RCHOPP done for?
4-6
What is ALL maintenance therapy?
Methotrexate + Mercaptopurine
(Maybe monthly vin & cortico)
What type of GVH is glucocorticoid used for?
1st line
What type of GVH are calcineurin inhibitors used for?
Cadaver
What type of GVH is sirulimus used for?
Steroid refractory
What side effects do all immunosuppressants share?
HTN & headaches
What is mycophenolate used as a first line for?
Chronic allograft vasculopathy in cardiac transplant
What side effect does tacrolimus have that is not seen in cyclosporin?
Diabetes mellitus (from hyperglycemia)
How does cyclosporin supress T-cells?
Cyclosporin-Cyclophillin inhibits calcineurin which inhibits NFAT which inhibits IL production
How does Tacrolimus inhibit T-cells?
Tacrolimus-FKBP inhibits calcineurin which inhibits NFAT which inhibits IL production
How do Sirulimus & Everolimus inhibit T-cells?
They bind with FK506BP12 which inhibits mTOR which inhibits IL production
How does Tofacitinib work?
It inhibits JAK enzyme which reduces NK ,immunoglobulins & C-reactive proteins in the blood
What is tofactinib used for ?
Severe Rheumatoid arthritis
What is tofactinib’s black box for?
Infections & malignancy
How does thialidomide work?
1) It decreases TNF & IL-10 thus decreasing neutrophils
2) increase T-cell activity
How does azathioprine work?
Inhibits purine production
How does cyclophosphamide work?
Alkylating agent
