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HLS > Lymphoma > Flashcards

Lymphoma Flashcards

1
Q

What does the submandibular lymph node drain?

A

The face

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2
Q

What does the preauricular lymph node drain?

A

Scalp & skin

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3
Q

What does the epitrochlear lymph node drain?

A

Ulnar foreman & hands

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4
Q

What antigens prove that reed-stenberg cells originated from b-lymphocytes?

A

PAX5 & MUM1

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5
Q

How can identification of hodgkin cells help us ?

A

They help identify extra-nodal sites in known cases

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6
Q

When is hodgkin lymphoma considered stage 1?

A

1 nodal / extra-nodal region

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7
Q

When is hodgkin lymphoma considered stage 2?

A

2 nodal regions on the same side of the diaphragm

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8
Q

When is hodgkin lymphoma considered stage 3?

A

Nodal regions on both sides of diaphragm + spleen maybe

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9
Q

When is hodgkin lymphoma considered stage 4?

A

Diffuse extralymphatic disease

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10
Q

% of SLL in NHL?

A

4%

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11
Q

What is the transformation of SLL into DLCL called?

A

Richter’s transformation

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12
Q

% of Folicular lymphoma patients from all NHL?

A

40%

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13
Q

What mutation causes most of follicular lymphomas?

A

BCL2 on chr. 18 translocating into chr. 14 (Heavy Ig)
t [14:18]

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14
Q

What identifies grade 1 follicular lymphoma ?

A

0-5 centroblasts

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15
Q

What identifies grade 2 follicular lymphoma ?

A

6-15 centroblasts

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16
Q

What identifies grade 3 follicular lymphoma ?

A

> 15 centroblasts

17
Q

% of mantle cell lymphoma patients out of all NHL patients?

A

5%

18
Q

What mutation causes mantle cell lymphomas?

A

Cyclin D1 on chr. 11 translocates to chr. 14 (Heavy Ig)
t [11;14]

19
Q

% of DLCL out of all NHL patients?

A

20%

20
Q

What mutations causes diffuse large cell lymphomas?

A

30% by BCL6 point mutation
30% by BCL2 over-expression

21
Q

What mutation causes burkitt lymphoma?

A

Translocation of c-myc on chr. 8 to chr. 14 (heavy Ig)
t [8;14]

22
Q

What causes B-symptoms ?

A

Reactive cells

23
Q

CD markers of classical Hodgkin lymphoma

A

CD15 & CD30

24
Q

What is the RS cell type found in Nodular sclerosing Hodgkin lymphoma ?

A

Lacunar cells

25
Q

What is the reactive cell type found in Nodular sclerosing Hodgkin lymphoma ?

A

Fibroblasts

26
Q

What is the RS cell type found in Nodular lymphocyte predominant Hodgkin lymphoma ?

A

Popcorn cell (PL)

27
Q

Symptoms of Hodgkin lymphoma?

A

Painless lymphadenopathy & B-symptoms

28
Q

What type of lymphocytes is reactive in hodgkin lymphoma?

A

T- helper cells

HLS (13 decks)

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