Cholelithiasis/Cholangitis Flashcards
bile
general
Yellow-brown or yellow-green alkaline fluid continuously formed in the liver
~1 liter produced per day
Drains into the gallbladder for storage
Composed of:
Cholesterol (10%), bilirubin (1%), water, bile salts (70%), phospholipids (5%), and proteins (5%), electrolytes, and bicarbonate
bile
essential for? (3)
Digesting (emulsification) fats
Excreting cholesterol – how most of the cholesterol in the body is excreted
Antimicrobial activity
The Biliary Tree
general
Series of ducts within the liver, gallbladder, and pancreas that empty into the small intestine
Components:
intrahepatic (within the liver)
extrahepatic (outside the liver)
biliary tree
flow of bile
Gallbladder → cystic duct → common bile duct → addition of the pancreatic duct to the common bile duct → duodenum through the ampulla of Vater
Physiology of the Gallbladder
Store, concentrate, and when stimulated, releases bile into the duodenum via the common bile duct
Fatty foods and proteins entering the duodenum signal the release of cholecystokinin (CCK)
Cholecystokinin
Peptide hormone released by I-cells (i) located in the duodenum and jejunum
Two functions in relation to the gallbladder:
Stimulate the smooth muscle of the gallbladder to contract and release bile into the biliary tree
Signal the muscular sphincter of Oddi to relax
Cholelithiasis
general
One or more calculi (gallstones) in the gallbladder
Produced when there is an imbalance in the constituents of bile and biliary sludge secondary to gallbladder hypokinesis (bile is not flowing)
Gallstone classification (3)
Cholesterol stones
black pigmented stones
brown pigmented stones
Insoluble stones can lead to physical blockages in the biliary tree and beyond
Cholesterol stones
80% of stones
Most often associated with the risk factors - estrogen, obesity, multiparity, and advancing age
6 F’s mnemonic – female, fat, fertile, forty, fair, family history
Pigmented stones
Brown
Soft and greasy
Form secondary to infection, inflammation, or parasitic infestation in the biliary ducts
Pigmented stones
Black
Composed of calcium bilirubinate
Secondary to conditions that cause hemolysis (sickle cell anemia)
Radiopaque…visible on x-ray
Cholelithiasis
RF
Female sex
Obesity
Increased levels of estrogen (pregnancy)
Prolonged fasting
Low calorie, rapid weight-loss diets
Advanced age
Native Americans
Mexican-Americans
Family history of gallbladder disease
estrogen increases cholesterol stones
cholelithiasis
S/Sx
Often asymptomatic – “silent stones”
Biliary colic
Severe, sudden right upper quadrant pain lasting a few minutes to several hours
Postprandial
Nocturnal
Referred pain straight through to the back
Due to temporary obstruction (usually by stones) in the cystic duct or common bile duct
Nausea and vomiting
Abdominal bloating
should have NEGTIVE murphy sign and NO fever
cholelithiasis
Complications of Gallstones
Acute Cholecystitis
Gallstone pancreatitis
Choledocholithiasis- stone in common bile duct
Cholangitis- infection from obstruction
Gallstone ileus
Prolonged blockage of any biliary ducts can cause severe damage to the gallbladder, liver, or pancreas
cholelithiasis
Surgical Tx
Indications
Cholecystectomy
Most common method for treating symptomatic gallstones, asymptomatic large gallstones (>3 cm), and porcelain gallbladder
Types:
Open cholecystectomy
Laparoscopic cholecystectomy – 95%
Porcelain Gallbladder
general
Also known as a calcified gallbladder
Not a gallstonebut often found in conjunction with gallstones
Calcifications in thegallbladderwall, with mechanism the same as gallstones
Gallbladder wall becomes brittle, hard, and often takes on a bluish hue
Absences of Courvoisier’s sign
Increased risk ofgallbladder cancer
no murphy or fever. No courvoisier’s sign
choledocolithiasis
ERCP (endoscopic retrograde cholangiopancreatography)
Diagnostic and therapeutic
Gold standard for diagnosing cholangitis
