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PharCare > Cholera > Flashcards

Cholera Flashcards

1
Q

Acute diarrheal infection caused by a bacterium; water-borne disease; rapidly fatal illness

A

Cholera

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2
Q

Causative agent of Cholera

A

Vibrio Cholera

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3
Q

Family of Vibrio Cholera

A

Vibrionaceae

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4
Q

Synonyms of Cholera

A 
Asiatic Cholera
Epidemic Cholera
Indian Cholera
Gastroenteritis Cholera
Blue Death
Cholera Infantium
Curse of the 19th Century 
Stomach Bug
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5
Q

3 Theories on the Origin of Cholera

A
  1. Germ Theory
  2. Miasma theory
  3. Blood Generation Theory
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6
Q

Theory: Cholera caused by germ cell

A

Germ Theory

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7
Q

Germ theory proposed by

A

John Snow

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8
Q

Theory: cholera caused by bad air arising from decayed organic matter or miasmata

A

Miasma Theory

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9
Q

Miasma theory proposed by

A

Dr. William Farr

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10
Q

Theory: Spontaneous generation of disease within the blood; fermentation of blood

A

Blood Generation Theory

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11
Q

Blood Generation theory proposed by

A

Justus von Leibig

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12
Q

Miasma was thought to be the cause of transmission of the great disease

A

The Great Stink

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13
Q

Soho District, London; serious problem with filth due to the large influx of people and lack of properly sanitary services

A

Broad Street Pump

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14
Q

Discovered that water spread the infection

A

John Snow

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15
Q

Original reservoir of Cholera

A

Ganges Delta in India

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16
Q

Comma bacillus that is facultatively anaerobic; gram negative; non-spore-forming; motile by means of active, single sheathed, polar flagellum

A

Vibrio Cholera

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17
Q

Capable of fermentative and respiratory metabolism

A

Vibrio Cholera

18
Q

Grows at high pH; killed by acid easily; oxidase-positive

A

Vibrio Cholera

19
Q

Cholera is invasive or non-invasive

A

Non-invasive

20
Q

Only serotype of cholera that produces heat-labile enterotoxin

A

Serotype 01 and 0139

21
Q

Associated w/ the endemic characteristics of Cholera

A

01 and 0139

22
Q

Showed agglutination in 0 antiserum

A

Serotype 01

23
Q

Original Serotype; express A and B antigens and small amount of C

A

Serotype Ogawa

24
Q

Variant serotype; Antigen A and C

A

Serotype Inaba

25
Q

Middle serotype; rare and unstable; all three antigens

A

Serotype Hikojima

26
Q

Bengal strain: derived from El Tor pandemic strain

A

Serogroup 0139

27
Q

Possess virulence factor of VC 01 El Tor; deletion of genes

A

VC 0139

28
Q

causes majority if outbreaks and more severe in epidemic cholera

A

VC 01

29
Q

First identified in Bangladesh; confined to SE asia

A

VC 0139

30
Q

Virulence factor that causes severe watery diarrhea

A

CT; Choleragen; Cholera Toxin

31
Q

Pilus required for colonization; adherence to mucosal lining; receptor for CT carrying phage

A

Toxin Coregulated Pili (TCP)

32
Q

Help reach intestinal mucosa and auds in colonization

A

Flagellar motility

33
Q

2 Types of adhesins for Cholera

A

Hemaglutinnin

ACF (Accessory Colonization Factor)

34
Q

Surface protein that agglutinates RBC

A

Hemagglutinin

35
Q

Assisting in intestinal colonization

A

ACF (Accessory Colonization Factor)

36
Q

For colonization, chemotaxis, adherence to mucosal laters, hydrolyses sialic acid, NANA (N-acetylneuramic acid)

A

Neuraminidase

37
Q

Colonizes intestines and produces cholera (OmpU and OmpT)

A

Outer Membrane Porins

38
Q

Absence of CT:

A

Accessory Cholera Enterotoxin

Zonnula Occludens Toxin

39
Q

Increases fluid secretion

A

Accessory Cholera Enterotoxin

40
Q

Looses tight junction of small intestine mucosa, leading to increased intestinal permeability

A

Zonnula Occludens Toxin

PharCare (5 decks)

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