Cholera

Question 1

Acute diarrheal infection caused by a bacterium; water-borne disease; rapidly fatal illness

Answer 1

Cholera

Question 2

Causative agent of Cholera

Answer 2

Vibrio Cholera

Question 3

Family of Vibrio Cholera

Answer 3

Vibrionaceae

Question 4

Synonyms of Cholera

Answer 4

Asiatic Cholera
Epidemic Cholera
Indian Cholera
Gastroenteritis Cholera
Blue Death
Cholera Infantium
Curse of the 19th Century 
Stomach Bug

Question 5

3 Theories on the Origin of Cholera

Answer 5

1. Germ Theory
2. Miasma theory
3. Blood Generation Theory

Question 6

Theory: Cholera caused by germ cell

Answer 6

Germ Theory

Question 7

Germ theory proposed by

Answer 7

John Snow

Question 8

Theory: cholera caused by bad air arising from decayed organic matter or miasmata

Answer 8

Miasma Theory

Question 9

Miasma theory proposed by

Answer 9

Dr. William Farr

Question 10

Theory: Spontaneous generation of disease within the blood; fermentation of blood

Answer 10

Blood Generation Theory

Question 11

Blood Generation theory proposed by

Answer 11

Justus von Leibig

Question 12

Miasma was thought to be the cause of transmission of the great disease

Answer 12

The Great Stink

Question 13

Soho District, London; serious problem with filth due to the large influx of people and lack of properly sanitary services

Answer 13

Broad Street Pump

Question 14

Discovered that water spread the infection

Answer 14

John Snow

Question 15

Original reservoir of Cholera

Answer 15

Ganges Delta in India

Question 16

Comma bacillus that is facultatively anaerobic; gram negative; non-spore-forming; motile by means of active, single sheathed, polar flagellum

Answer 16

Vibrio Cholera

Question 17

Capable of fermentative and respiratory metabolism

Answer 17

Vibrio Cholera

Question 18

Grows at high pH; killed by acid easily; oxidase-positive

Answer 18

Vibrio Cholera

Question 19

Cholera is invasive or non-invasive

Answer 19

Non-invasive

Question 20

Only serotype of cholera that produces heat-labile enterotoxin

Answer 20

Serotype 01 and 0139

Question 21

Associated w/ the endemic characteristics of Cholera

Answer 21

01 and 0139

Question 22

Showed agglutination in 0 antiserum

Answer 22

Serotype 01

Question 23

Original Serotype; express A and B antigens and small amount of C

Answer 23

Serotype Ogawa

Question 24

Variant serotype; Antigen A and C

Answer 24

Serotype Inaba

Question 25

Middle serotype; rare and unstable; all three antigens

Answer 25

Serotype Hikojima

Question 26

Bengal strain: derived from El Tor pandemic strain

Answer 26

Serogroup 0139

Question 27

Possess virulence factor of VC 01 El Tor; deletion of genes

Answer 27

VC 0139

Question 28

causes majority if outbreaks and more severe in epidemic cholera

Answer 28

VC 01

Question 29

First identified in Bangladesh; confined to SE asia

Answer 29

VC 0139

Question 30

Virulence factor that causes severe watery diarrhea

Answer 30

CT; Choleragen; Cholera Toxin

Question 31

Pilus required for colonization; adherence to mucosal lining; receptor for CT carrying phage

Answer 31

Toxin Coregulated Pili (TCP)

Question 32

Help reach intestinal mucosa and auds in colonization

Answer 32

Flagellar motility

Question 33

2 Types of adhesins for Cholera

Answer 33

Hemaglutinnin | ACF (Accessory Colonization Factor)

Question 34

Surface protein that agglutinates RBC

Answer 34

Hemagglutinin

Question 35

Assisting in intestinal colonization

Answer 35

ACF (Accessory Colonization Factor)

Question 36

For colonization, chemotaxis, adherence to mucosal laters, hydrolyses sialic acid, NANA (N-acetylneuramic acid)

Answer 36

Neuraminidase

Question 37

Colonizes intestines and produces cholera (OmpU and OmpT)

Answer 37

Outer Membrane Porins

Question 38

Absence of CT:

Answer 38

Accessory Cholera Enterotoxin | Zonnula Occludens Toxin

Question 39

Increases fluid secretion

Answer 39

Accessory Cholera Enterotoxin

Question 40

Looses tight junction of small intestine mucosa, leading to increased intestinal permeability

Answer 40

Zonnula Occludens Toxin