Cholesterol Targets Flashcards
(24 cards)
Total cholesterol target
Less than 5
Total HDL target (good)
More than 1
Non HDL target bad
Less than 2.6
LDL target bad
Less than 2
Non fasting triglycerides target
Less than 2.3
Name statins
Atorvastatin
Rosuvastatin
Simvastatin
Fluvistatin
Pravastatin
Which statins can be taken at any time in day
Atorvastatin
Rosuvastatin
Statins monitoring before initiation
HbA1c/fasting BG - repeat after 3 months as statins can cause HYPERglycaemia
Full lipids
Thyroid
Lfts
Egfr
When to discontinue statin in regards to lfts
When to monitor lfts
Lfts before, 3 months and 12 months
Discontinue if serum transaminases are raised by more than 3x the upper limit
When to stop statin in regards to creatinin kinase
If more than 5x upper limit remeasure in 7 days
If still more than 5x DO NOT initiate statin. STOP STATIN
If levels are less than 5x upper limit start at lower dose
Statin side effects
Myopathy/rhabdomyolysis - medical attention
Interstitial lung disease - medical attention
Teratogenic - stop 3 months prior to pregnancy
CYP450s
Hyperglycaemia
Statin interactions
Oral fusidic acid - stop statin during treatment restart 7 days after last dose
Clarithromycin
Statins max dose amlodipine vs simvastatin
20mg
Statin max dose amiodarone simvastatin
20mg
Statin max dose diltiazem/verapamil and simvastatin
20mg
Statin max dose elbasvir/grazoprevir and simvastatin
20mg
Which drugs interact with simstatin that need to be reduced to 20mg
Amlodipine
Amiodarone
Diltiazem/verapamil
Elbasvir with grazoprevir
Statin max dose fibrates (not fenofibrate) and simvastatin
10mg
Which drugs reduces simvastatin dose to 10mg
Fibrates but not fenofibrate
Statin max dose ciclosporin and atorvastatin
10mg
Statin max dose tipranavir and atorvastatin
10mg
Which drugs reduce atorvastatin dose to 10mg
Ciclosporin
Tipranavir
What is 2nd line lipid lowering therapy and side effects
Ezetimibe
Myopathy and rhabdo
What is 3rd line lipid lowering drugs
Fibrates - bezafibrate, ciprofinrate, fenofibrate, gemfibrozil
